PREVALENCE OF MULTIDRUG-RESISTANT (MDR) AMONG CLINICAL BACTERIAL ISOLATES IN EL-GHARBIA GOVERNORATE AND EFFICIENCY OF ANTIBIOTIC COMBINATIONS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 10
Abstract
Prevalence of multidrug-resistance (MDR) bacteria represents a great problem worldwide. Survey to determine the susceptibility profile of clinical bacterial pathogenic strains to the most commonly prescribed antibiotics by physicians in Egyptian hospitals have been determined between 20/5/2013 to 15/9/2014. Out of 200 bacterial isolates, 144(72%) were Gram-negative bacilli (GNB), 54(27%) Gram-positive cocci and two (1%) were Candida spp. The most frequent pathogens were Klebsiella spp. (42%) followed Staph. aureus (16%) and E.coli (15.5%). The most resistant isolates were Pseudomonas spp. (79 %). The most efficient antibiotic was amikacin (AK) (48.5%), while most bacterial isolates were resistant to spectinomycin (SPT) (93%). The results showed that aminoglycoside antibiotics were the most efficient agents against the clinical bacterial isolates. And from the beginning to the end of the collection period, it was found that MDR bacterial isolates 186 isolates out of 200 (93%), these MDR involved 59 XDR isolates which represented 29.5%. The sensitive isolates were found to be 14 isolates (7%) from all the isolated strains. The results of MIC50 proved that amikacin (AK) having the lowest MIC against most MDR strains tested when compared with the two other antibiotics (aztreonam (ATM) and meropenem (MERO)). This results confirmed the previous results of the present study that AK was the most effective antibiotics. The percentage of growth inhibition of double, triple and four antibiotic combinations revealed that inhibition exceeded 95% for most combinations.
Authors and Affiliations
Mervat Aly Abo-State
Keywords
Related Articles
- EP ID EP618917
- DOI -
- Views 125
- Downloads 0
CONCEPT OF ASHRU VS. ASHRUVEGA (TEAR REFLEX) IN AYURVEDA
of us display different emotions using different expressions. The body too has some expressions. These body expressions come in the form of natural body reflexes or urges. Ayurveda calls them Vegas. Ayurveda explains dif...
INCIDENCE, PREVENTION AND MANAGEMENT OF CATHETER ASSOCIATED URINARY TRACT INFECTION
Catheter associated urinary tract infection attributed to the use of an indwelling urinary catheter is one of the most common infection acquired by patients in health care facilities. As biofilm ultimately developed on a...
CHARAK’S CHATURVIMSHATI UPKRAMA AND ITS CONTEMPORARY VIEW
Poison has been polluting human and non-human forms since antiquity. Our acharyas had given a separate place for Agadtantra that deals with the management of animate and inanimate poisoning. Since ancient time Agadtantra...
SYNERGISTIC EFFECT OF GALANTAMINE CARRIED ON A NOVEL NANO-DRUG DELIVERY SYSTEM ON INDUCED LUNG DISORDERS IN ALZHEIMER’S DISEASE
Alzheimer's disease AD, the most common form of dementia, usually presents with lung disorders including lung fibrosis. The aim of the present study was to verify that the curative role of Galantamine (the major therapeu...
SODIUM AZIDE INDUCED MUTAGENESIS IN WHEAT PLANT
Sodium azide, a chemical mutagen has become important tool to enhance agronomic traits of crop plants. It is being used to produce resistance in various susceptible crops to improve their yield and quality traits against...