Prevention of Crystal Formation during Formulation of Acyclovir Powder for Solution for Infusion
Journal Title: Journal of Pharmaceutics & Pharmacology - Year 2015, Vol 3, Issue 2
Abstract
Aims and objectives: The main objective of the present work is to develop acyclovir powder for solution for infusion with clear solution upon half sealing and formation of stable cake after freezing drying programme. During the development, after half sealing stage, a mild turbid color formation in vials was observed followed by crystal formation. This was later investigated due to presence of residual oxygen content in the headspace of the vial and also in freeze drying chamber. Material and method: Aciclovir, sodium hydroxide and cool water for injection was used to prepare solution for injection. Followed by pre-filtration and sterile filtration into colorless vials and semi seal the vials in freeze-drying mode with rubber stoppers. Final freeze-drying programme was performed and cap them with aluminum caps. Results and discussion: Trial 3 showed stable clear solution after few hours. This was due to lower concentration of oxygen in the headspace, which was obtained due to introduction of nitrogen during filling stage. Conclusion: Crystal formation was due to presence of oxygen in the head space, which can be avoided by maintaining oxygen level below 0.5% in headspace volume of vials and also stable formed after changing the freeze drying cycles.
Authors and Affiliations
Himankar Bashiya
Keywords
Related Articles
- EP ID EP198090
- DOI 10.13188/2327-204X.1000017
- Views 82
- Downloads 0
The Role of Protein S-Nitrosylationin Alzheimer’s Disease and its Treatment
As a post-transcriptional modification, S-nitrosylation is a covalent binding of nitric oxide to cysteine thiols in proteins to form S-nitrosothiols. Nitric oxide is recognized as an important signaling molecule, and has...
Prevention of Crystal Formation during Formulation of Acyclovir Powder for Solution for Infusion
Aims and objectives: The main objective of the present work is to develop acyclovir powder for solution for infusion with clear solution upon half sealing and formation of stable cake after freezing drying programme. Dur...
NMDA Receptor Antagonism by Phencyclidine Reduces NWASP and WAVE1 Protein Expression and Reduces Levels of Myelination Markers in the Prefrontal Cortex of Rats
N-methyl-D-aspartate (NMDA) receptor antagonism by perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. It is routinely used to model pathological proc...
Molecular Inclusion Complexes of β-Cyclodextrin Derivatives Enhance Aqueous Solubility and Cellular Internalization of Paclitaxel: Preformulation and In vitro Assessments
Drugs with low aqueous solubility and permeability possess substantial challenges in designing effective and safe formulations. Synergistic solubility and permeability enhancement in a simple formulation can increase bio...
Effect of Centruroides Antivenom on Reversal of Methamphetamine-Induced Hyperkinesis and Hyperthermia in Rats
Context: Methamphetamine (MA) toxicity is a major health concern causing agitation, hyperkinesia, hyperthermia, and even death, affecting 24.7 million people worldwide. It has been observed that MA generates movement dis...