Primer hipotiroidizm ve miyopati birlikteliği
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 1
Abstract
Tiroid hormonu eksikliği hipotiroidizme neden olur ve primer hipotiroidizmde serbest T3 ve T4 düzeyinde düşme, TSH düzeyinde yükselme görülür. Klinik bulgular, jeneralize kas güçsüzlüğü, letarji, yorugunluk, konuşma ve düşünmede yavaşlama, soğuk intoleransı, bradikardi, menstruel düzensizlik, depresyon, konstipasyon ve kilo artışı ile karakterizedir. Ayrıca, miyopati ve duysal-motor aksonal nöropati gibi nöromüsküler bulgularda görülebilir. 28 yaşındaki erkek hasta yorgunluk, soğuk intoleransı, mental küntlük, kramplar ve güçsüzlük yakınması ile kliniğe kabul edildi. Serbest T3 ve T4 düzeyleri sırasıyla 0.27 ng/dl and 0.10 pg/ml TSH düzeyi 135.52 mIU/L idi. CPK, SGOT ve SGPT düzeyleri yüksekti (4869 U/L , 156 U/L, 60 U/L). Olgu öykü, fizik ve nörolojik muayene, histopatolojik inceleme ve laboratuar analizlerine dayanarak myopatinin eşlik ettiği primer hipotiroidizm olarak tanındı ve Levotiroksin sağaltımı başlandı. Klinik ve laboratuar bulguları tedrici olarak düzeldi.
Authors and Affiliations
A KOC, Ali OZEREN, Suzan ZORLUDEMIR, Gamze ALMAK
Keywords
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