Production of Rifamycin using Nocardia mediterranea (ATCC 13865)
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 4
Abstract
The U.V. irradiation to Nocardia mediterranea ATCC 13865 for 10, 20, 30, 40, 50, 60, 70, up to 120 minute the maximum (581µgml-1) production of rifamycin was found developed S-10 strain for maximum production of rifamycin antibiotics (optimum time 15 minute) for further enhancement of rifamycin various parameter like age and size inoculum, pH of the culture medium, various carbohydrate, various amino acids, temperature, various Carbone sources, aeration were optimized. The maximum rifamycin conc. of 570 µgml-1 at 4.50 inoculums % with the age of 48 hrs. Inoculum was given even maximum rifamycin production with various age of inoculums (24, 36, 48, 60, 72 hrs.) with corresponding inoculums % (1.5, 2.5, 3.5, 4.5) in culture media, the optimum rifamycin 485 and 480 µgml-1 of rifamycin was producing M-6 and M-8 respectively medium amongst M-1, 2, 3, 4, 5, 6, 7, 8, 9 and M-10.
Authors and Affiliations
Suneel Kumar Niranjan| Institute of Pharmacy, Shri Venkateshwara University, Gajroula, Uttar Pradesh, India, Chandrul Koushal| Institute of Pharmacy, Shri Venkateshwara University, Gajroula, Uttar Pradesh, India, S. K. Jain| Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Pradesh, India
Keywords
Related Articles
- EP ID EP16026
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2693-2
- Views 288
- Downloads 15
SAFETY ASSESSMENT OF DIABECON: AN AYURVEDIC FORMULATION IN RATS
Diabecon an ayurvedic formulation was tested for safety by estimation of heavy metal contents and also for acute and sub chronic toxicity. Heavy metal content in formulation were tested and found to be within limit as p...
FUNCTIONALITY ADVANCEMENT OF POORLY SOLUBLE BIOVARIABLE ANTI HYPERTENSIVE DRUG BY SOPHISTICATED SD-FBP TECHNOLOGY AS PER ENHANCED QbD
Lacidipine (LCDP) is a dihydropyridine derivative categorized as an Anti-hypertensive Ca+2 channel blocker belonging to BCS class IV drug with low solubility and low permeability which presents a challenge to the formul...
FLOATING DRUG DELIVERY SYSTEM
The aim of writing this review on gastro retentive and floating drug delivery system was to compile the new literature with the principle mechanism of floatation to acquired gastric retention. Various attempts have been...
AN OVERVIEW ON MICROWAVE MEDIATED SYNTHESIS
Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. Microwave organic synthesis opens up new opportunities to the synthetic chemist in the form of ne...
Optimization of Diesel oil degrading Bacterial strains at various culture parameters
Environmental pollution with petroleum has been recognized as one of the most serious current problems. Petroleum hydrocarbons are a combination of hydrocarbons obtained from reservoirs of crude petroleum. The petroleu...