PROFILE OF PULMONARY INFECTIONS IN RENAL TRANSPLANT PATIENTS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 3
Abstract
BACKGROUND Renal transplantation is a successful therapy for patients with end-stage kidney disease. In a country like India, where tuberculosis is highly prevalent, it poses immense diagnostic challenge. Proper knowledge about the microbiological spectrum would help to start appropriate therapy empirically, awaiting confirmation. The aim of the study is to study the microbiological profile of lower respiratory tract infections in renal transplant recipients. MATERIALS AND METHODS Consecutive patients who presented to the transplant clinic with cardinal respiratory symptoms and fever were screened radiologically and an attempt to make a microbiological diagnosis was done with sputum or bronchial wash wherever needed. Setting- Prospective observational study conducted in the Department of Nephrology, Transplant Clinic, Rajiv Gandhi Government General Hospital and Madras Medical College. Post-renal transplant patients were followed up for 2 years between October 2014 - October 2016 and the development of pulmonary infection and the number of episodes were systematically recorded. RESULTS A total of 32 episodes of pulmonary infections were observed in 29 patients (23 males and 6 females). Bronchial wash had higher diagnostic yield than sputum. Triple drug immunosuppression comprising cyclosporine, prednisolone and azathioprine (75.8%) and episodes of acute graft rejection requiring pulse methylprednisolone (37.93%) were important prerequisites for developing pulmonary infection. Pseudomonas 12 (3%), Klebsiella 8 (25%) and Mycobacterium tuberculosis 8 (25%) were the most common organisms recovered. CONCLUSION Aggressive diagnostic modalities should be carried out for establishing the diagnosis. Empirical regimens should cover for Pseudomonas and Klebsiella. Tuberculosis should be sought for keenly. Mixed infections were also common in the study.
Authors and Affiliations
Sundararajaperumal Anandhakrishnan, Murugan Natarajan, Karthick Rajendran, Harikrishnan S
Keywords
Related Articles
- EP ID EP450642
- DOI 10.18410/jebmh/2018/53
- Views 73
- Downloads 0
MAGNETIC RESONANCE IMAGING IN EVALUATION OF PAINFUL HIP JOINT
BACKGROUND Magnetic resonance imaging is an imaging modality that provides excellent soft tissue resolution, and with its multiplanar capability provides an excellent anatomical and biomechanical details and information....
ULTRASOUND GUIDED SELECTIVE NERVE BLOCKS IN THE MANAGEMENT OF HAND INJURY: A CASE REPORT
Regional anesthesia has proved to be very useful in ambulatory upper limb surgery. This technique along with ultra-sonogram guide has refined the whole concept of peripheral nerve blocks. Peripheral nerve blocks have pro...
OUTCOME OF PREGNANCY IN ELDERLY GRAVIDAE
BACKGROUND Advanced maternal age, generally held to signify 35 years of age at the time of delivery is the term that implies decreased fertility and increased risk. The changing role of women in the work place with more...
DETECTION OF HAEMOGLOBINOPATHIES USING HAEMOGLOBIN ELECTROPHORESIS IN MICROCYTIC HYPOCHROMIC ANAEMIA IN PAEDIATRIC POPULATION OF SOUTHERN ODISHA
BACKGROUND Anaemia is the most common symptom in the developing countries including India where under nutrition is prevalent besides haemoglobinopathy is also prevalent in this geographic region. Haemoglobinopathies espe...
CLINICAL PRESENTATION AND HISTOPATHOLOGICAL CORELATION IN THE MANAGEMENT OF BREAST TUMOUR
To plan the line of management for carcinoma breast as per the clinical and histopathological findings. OBJECTIVES: To study various clinical presentations of breast cancer and its co-relation with histopathological patt...