Profile of the variation of the Serum albumin and albuminuria in type 2 diabetes in the Democratic Republic of Congo
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
Introduction: Kidney failure is a serious complication of diabetes type 2. The presence of albumin in urine is an important marker that should alert on kidney disease. The first detectable manifestation of diabetic nephropathy is the increase of albumin in urine. Our objective was to determine the profile of the serum albumin and albuminuria in patients with diabetes type 2 in a Congolese population. Patients and methods: This is a case-control study conducted from March 10 to June 8, 2015 in Lubumbashi ( DR Congo ) where assays of serum and urinary albumin were performed in cases consist of 30 type 2 diabetics older than 30 years ( group I) and in controls consist of 30 non- diabetic patients ( group II). Definition of concept: The results obtained were compared in the two groups and the level of significance was set at p <0.05. Results: The average age of 30 diabetic patients (55 ± 6 years) was comparable to that of 30 controls (56 ± 3 years). The mean serum albumin was 33.8 ± 3.66 g / L in group I against 38.12 ± 2.16 g / L in group II. A decrease in albumin in the blood was found in 53% of cases and no controls (p ≤ 0.05). The average of albuminuria was 36.7 ± 7.8 mg / 24 hours in group I while it was 32.2 ± 5.1 mg / 24 hours in group II. An increase in albuminuria was found in 23 % of diabetics against 7 % of controls (p ≤ 0.05). Conclusion: A decrease in serum albumin and a significant albuminuria have characterized diabetics patients with type 2 Congolese.
Authors and Affiliations
Arsène Kabamba Tshikongo, Elie Rongorongo Kagowa1 ,, Richie Kipenge Kyandabike2, Christian Kasongo Busambwa1, Rachel Mujinga Kayembe1, Dominique Mudimbi Kalonda1, Albert Longanga Otshudi1 ,, Zet Lukumwena Kalala 4
Keywords
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- EP ID EP383260
- DOI 10.9790/3008-11116669 .
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