Cytoprotective And Anti Ulcer Activities of The Ethanolic Leaf Extract of Irvingia Gabonensis on Aspirin-Induced Ulcer
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
This study evaluated the gastroprotective and hepatoprotective effects of ethanolic leaf extract of Irvingia gabonensis on aspirin-induced ulcer in albino rats. The animals were grouped into 5 groups of 5 rats each with Group 1 (Control), Gp 2 (Aspirin alone ASA 400mg/kg), Gp 3 (Omeprazole 20mg/kg + ASA 400mg/kg), Gp 4 (200mg/kg Extract + ASA 400mg/kg( and Gp 5 (400mg/kg Extract + ASA 400mg/kg). The result of the study showed a significant decrease (p≤0.05) in ulcer score, ulcer index, volume of gastric content, total acidity and pepsin activity. There was an increase observed in ulcer percentage inhibition in wistar rats pretreated with 20 mg/kg omeprazole, 200 mg/kg and 400 mg/kg of ethanolic leaf extract of Irvingia gabonensis when compared with the untreated group. The liver enzyme levels were also estimated using standard analytical method. There was a significant decrease on serum alanine transaminase (ALT) and serum aspartate transaminase (AST) but an increase in alkaline phosphatase (ALP) of the group pretreated with ethanolic leaf extract of Irvingia gabonensis when compared to omeprazole and untreated group. The findings of the present study showed that ethanolic leaf extract of Irvingia gabonensis may possesses bioactive ingredients that elicited the hepatoprotective effect and antiulcer activity against the ulceration caused by aspirin.
Authors and Affiliations
Nosiri C. I, Atasie O. C, Idume J, Barney D
Keywords
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- EP ID EP394254
- DOI 10.9790/3008-1302011620
- Views 55
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