Proniosome based Transdermal Gels of Valsartan: Formulation, In-vitro and Ex-vivo Characterization
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Abstract: The present study is focused to evaluate the feasibility of proniosomes for transdermal delivery of valsartan. Proniosomes were prepared by varying the molar ratios of sorbitan monopalmitate (span 40) and cholesterol and were characterized for morphology, size, entrapment efficiency and rheological behavior. The niosomes formed upon hydration of proniosomes were spherical and multilamellar. In-vitro release studies across cellophane membrane indicate that the drug release follows zero order kinetics by diffusion. Further exvivo permeation study carried out using rat skin reveal a significant improvement in the permeation kinetics of valsartan from proniosomes compared to control. Among the formulations tested, the formulations containing low amounts of cholesterol showed a two to three fold enhancement in the permeation. The formulations are more stable when stored at refrigerated conditions compared to room temperature. In conclusion, proniosomes offer potential and provide suitable carriers for improved transdermal delivery of valsartan.
Authors and Affiliations
Ashok Mateti, Mohammed Habibuddin, Raju Jukanti
Keywords
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- EP ID EP391862
- DOI 10.9790/3008-1205066779
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