Prophylactic effect of lithium in bipolar affective illness may be related to serotonin transporter genotype.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 1
Abstract
Serotonin transporter promoter length polymorphism (5-HTTLPR) has been implicated in the pathogenesis of mood disorders and in the therapeutic response to serotonergic drugs. In this study, the 5-HTTLPR was estimated in 67 patients with bipolar mood disorder, receiving lithium carbonate for prophylactic purposes for the period of more than 5 years (mean 15 years). The patients were divided into excellent responders (n = 18), partial responders (n = 35) and poor responders (n = 14). In lithium non-responders, the genotype s/s and the allele s was significantly more frequent than in excellent and partial responders. The obtained results are discussed in view of other studies showing an association of S genotype with worse response to serotonergic drugs. A supposition is made that prophylactic management of bipolar illness can be optimized by defining 5-HTTLPR genotype.
Authors and Affiliations
Janusz Rybakowski, Aleksandra Suwalska, Piotr Czerski, Monika Dmitrzak-Weglarz, Anna Leszczynska-Rodziewicz, Joanna Hauser
Keywords
Related Articles
- EP ID EP154519
- DOI -
- Views 95
- Downloads 0
ESR techniques for the detection of nitric oxide in vivo as an index of endothelial function.
Plasma nitrite/nitrate levels reflect oxidation of formed nitric oxide (NO ) but are not indicative of endothelial nitric oxide synthase (eNOS) function due to interference by dietary nitrates and reactive oxygen species...
Sildenafil increases the force of right atrial contractions in vitro via the NO-guanylyl cyclase pathway involving beta-adrenoceptor linked mechanisms.
Sildenafil, a drug used in the treatment of erectile dysfunction, is a phosphodiesterase 5A inhibitor that increases cyclic guanosine monophosphate (cGMP) levels. In addition to its vascular actions, sildenafil is also k...
Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?
Lipoic acid (LA) was shown to possess anti-inflammatory properties. In this study, we present evidence supporting the hypothesis that the anti-inflammatory properties of LA are associated with the formation of hydrogen s...
Impact of ageing on the measurement of endothelium-dependent vasodilation.
Two established methods to assess endothelium-dependent vasodilation in the peripheral circulation have been used in epidemiological research, the invasive forearm technique using intra-brachial infusion of acetylcholine...
Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.
Extensive research into glutamate receptors in the central nervous system has shown important role of metabotropic glutamate receptors (mGluR) as potential targets for neuroprotective drugs. The aim of the present study...