PROPORTION AND GALECTIN 3 EXPRESSION OF THYROID MALIGNANCIES DEVELOPING IN MULTINODULAR GOITER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 12
Abstract
BACKGROUND Multinodular goiter (MNG) is traditionally thought to be a benign disease with an incidence of malignancy of less than 5 %, as compared to a solitary nodule of thyroid. Recent studies, however, suggest a higher risk of malignancy in patients with multinodular goiter (7-17%). The most common malignancy developing in MNG is papillary carcinoma. Several immunohistochemical markers are used to complement histopathological examination. Galectin-3 is a marker that is expressed in the malignant lesions of thyroid and its expression will help in the histological typing of the malignancies. MATERIALS AND METHODS This is a descriptive study done on all the specimens of multinodular goiter received in the Department of Pathology, Kottayam during the study period of one year. A total of 510 multinodular goiters specimens were studied. Histopathological examination of all the multinodular goiter specimens was done. Immunostaining for Galectin 3 expression (Gal-3) was also done. Multivariate analysis and logistical regression analysis were done. RESULTS Of 510 multinodular goiters, 49 cases (9.6%) had malignancy, constituted by 44 cases of papillary thyroid carcinoma, 3 cases of follicular carcinoma, one case each of anaplastic and poorly differentiated carcinoma. Gal-3 expression was positive in 79.6% of the malignancies. 82% of papillary thyroid carcinoma, 33% of follicular carcinoma and the cases of anaplastic and poorly differentiated carcinoma showed positive Gal-3 expression. CONCLUSION The majority of cases of multinodular goiter (MNG) were in females, in the age group 41-50. The proportion of malignancies in MNG was 9.6%. Papillary thyroid carcinoma was the commonest malignancy. Gal-3 can be used as an adjuvant to histopathology for the diagnosis of papillary thyroid carcinoma especially the classic variant and microcarcinoma.
Authors and Affiliations
Sreeja K, Lillykutty Pothen, Sankar S
Keywords
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- EP ID EP555685
- DOI 10.14260/jemds/2019/207
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