Protection Effect of Different Fractions of Root of Lawsonia inermis on 2-Deoxyribose by Hydroxyl (.OH) Radical Assay
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 17, Issue 6
Abstract
Aim: In vitro protective effect of different fractions of root of Lawsonia inermis (LI) on 2-deoxy ribose, sugar of the DNA were carried out in this study. Methods: Protective activity of different fractions of LI namely ethyle acetate (LIEAC), alcoholic (LIALC), petroleum ether (LIPET), buthanol (LIBUT) and aqueous (LIAQ) with different concentration were evaluated on 2-Deoxyribose (sugar moiety of the DNA) against hydroxyl radical as clastogen. Results: Protection of deoxyribose of DNA against hydroxyl radical induced damage was observed in all the fractions of LI, but LIEAC showed more protective activity. Conclusion: Protective activity of different fractions was due to anti-oxidant property which is directly related to total phenolic and flavonoid content but still further investigation required to claim the protective activity of these fractions.
Authors and Affiliations
Mina Basirian, V. Ch. Jeevani, S. N. Manjula, K. Mruthunjaya
Keywords
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- EP ID EP341908
- DOI 10.9734/BJMMR/2016/27856
- Views 73
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