PROTECTIVE AND ANTIDIABETIC EFFECTS OF VIRGIN COCONUT OIL (VCO) ON BLOOD GLUCOSE CONCENTRATIONS IN ALLOXAN INDUCED DIABETIC RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: The present study was carried out to evaluate if Virgin Coconut Oil (VCO) exerts any protective or regenerative effects on pancreatic β cells in Alloxan induced diabetic rats and to observe and determine the morphology of islets of animals from different treatment groups.Methods: Twenty six adults male Wistar rats were divided into 4 groups. Group 1 served as a control and received no treatment. Group 2 served as a diabetic control where they received 120 mg/kg body weight Alloxan at week 1. Group 3 was administered with Alloxan at 120 mg/kg body weight followed by VCO treatment for 10 w. Group 5 was administered with 0.8 ml VCO for 13 w prior to being administered with Alloxan 8 w after VCO treatment.Blood glucose readings and body weight were monitored weekly during the treatment period. IPGTT was carried out prior to animal sacrifice. Histological analysis was carried out on the pancreas of animals in VCO treated and control groups.Results: VCO treated rats were able to reduce hyperglycaemia in diabetic individuals. Histological analysis indicates that VCO was able to regenerate damaged islets of diabetic rats and was also able to prolong their survival despite being hyperglycaemic.Conclusion: VCO has potential protective and regenerative effects towards diabetic rats and further research should be evaluated to develop a probable mechanism of action.Â
Authors and Affiliations
Nur ‘azimatul Quddsyiah H. Maidin, Norhayati Ahmad
Keywords
Related Articles
- EP ID EP578214
- DOI -
- Views 58
- Downloads 0
SYNTHESIS AND FORMULATION OF IBUPROFEN PRO-DRUGS FOR ENHANCED TRANSDERMAL ABSORPTION
Objectives: The aim is to synthesize ibuprofen prodrugs that have more suitable physicochemical properties and formulate them into a liquid formulation for topical administration. The transdermal delivery (TDD) is one of...
FISHBURNE’s METHOD AND THE CLASSICAL METHOD OF PHARMACOECONOMIC ANALYSIS IN THE EVALUATION OF ANTIBIOTIC TREATMENT OF ACUTE AND RECURRENT BRONCHITIS IN CHILDREN
Objective: This study was performed in order to estimate clinical effectiveness of antibiotic therapy in acute and recurrent obstructive bronchitis. For estimation the following was used: the Fishbern method of antibioti...
THE EMERGENCE OF TIME PROGRAMMED DRUG DELIVERY SYSTEM: CHRONOTHERAPY OF CARDIO VASCULAR DISEASES
Time programmed drug delivery system is a system that promises to deliver a drug at a point of time when it is most required, as it is programmed beforehand. Though the delivery system is a boon to the pharmaceutical res...
BIOSYNTHESIS AND CHARACTERIZATION OF INTRACELLULAR TIO2NANOPARTICLES BY LACTOBACILLUS SP: AND ITS POTENTIAL APPLICATION IN DECOLOURIZATION OF METHYL ORANGE DYES
Objective: Nanotechnology is emerging as one of the most important and revolutionizing areas in the research field. Nanoparticles are produced by various methods like physical, chemical, mechanical and biological. Biolog...
ACUTE AND SUB-ACUTE TOXICITY STUDY OF AQUEOUS METHANOLIC LEAF AND BARK EXTRACT OF DOLICHANDRONE ATROVIRENS
Objective: The present study was to evaluate the oral toxicity of acute and sub acute studies of methanol leaf and bark extract of Dolichandrone atrovirensMethods: In acute toxicity studies of aqueous methanolic Dolichan...