Protective Effect of Dorema glabrum on Diazinon-induced Oxidative Stress in Rat Kidney
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 9, Issue 2
Abstract
Introduction: A wide number of pesticides such as diazinon (DZN) have deteriorating effect on fauna and flora by inducing oxidative stress and cell damage. The aim of current study was to investigate the protective effect of D. glabrum against the subchronic effect of DZN on serum urea and creatinine, oxidative damage markers such as lipid peroxidation (LPO) and the antioxidant defense system (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the kidney of male Wistar rats. Methods: Twenty-four adult male Wistar rats randomly divided into four groups including a control group, and three experimental groups. Two of three experimental groups received different doses of D. glabrum (40 and 80 mg/kg) as pre-treatment for 21 days along with DZN (100 mg/kg) that injected intraperitoneally in the last day of D. glabrum usage, and one group received only DZN (100 mg/kg). Results: The levels of LPO, urea, creatinine, and the decreased antioxidant defenses, like free radical scavenging enzymes viz., catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) significantly increased in DZN-treated group as compared to control group. Distinctly increased LPO levels, with alterations in endogenous antioxidant enzyme were evident in nephrotoxicity of DZN. Specific marker enzymes were restored to normalcy in rats supplemented with D. glabrum following treatment with DZN which otherwise was decreased in the DZN-treated rats. Conclusion: The obtained results revealed that the oxidative stress of rats treated via DZN can be decreased if it is co-treated by D. glabrum with DZN. In addition, this co-treatment might serve a putative protective agent against kidney damage generated by DZN.
Authors and Affiliations
Parisa Sistani, Mina Adampourezare, Gholamreza Dehghan, Amin Adami, Leila Mehdizadeh Fanid
Keywords
Related Articles
- EP ID EP351155
- DOI 10.9734/IJBCRR/2016/21998
- Views 84
- Downloads 0
Disulphide Bond Reduction of RNase A by Drug Metosartan a Comparative Study
RNase A is the most experimental protein in the 20th century. Disulphide bonds are necessary for enzymatic action of many proteins as it is also required for this protein. RNaseA kinetic studies is performed with the dru...
Biochemical Impacts of Radiation Processing on Grapes and Artichoke Agro Industrial Wastes
Food irradiation is a method of preservation used to extend the shelf life of food products fresh and/or dried, destroy the contaminating harmful pathogens and modify the activity of bioactive compounds present in food m...
Manganese, Zinc and Chloride Content of Milk of West African Dwarf Goats as Influenced by Stage of Lactation
The manganese, Zinc and chloride content in milk of West African dwarf (WAD) goats as influenced by stage of lactation was assessed using three WAD does aged 18 months of age, weighing from 19 to 20 Kg. They were kept fo...
The Effects of Aqueous Root Bark and Seed Extracts of Azadirachta indica in the Treatment of Ticks (Hyalomma spp) in vitro
The acaricidal effect of the aqueous extracts of neem (Azadrichta indica) seed and root bark on tick (Hyalomma spp) was investigated. Adult Hyalomma ticks of both sexes were incubated in aqueous extracts of neem seed and...
LH/FSH, BMI and Clinical Profile in Polycystic Ovarian Syndrome: A Correlative Study
Background and Objectives: Polycystic ovarian disease (PCOS) is probably the most prevalent endocrinological disorder affecting females and is the most common cause of menstrual disturbance during the reproductive age. I...