Protective Effect of Flowerbuds of Lonicera Japonica Extract on Diabetes Mellitus Type 2 and Associated Vascular Complications in STZ-HFD Treated Rats
Journal Title: International Journal of Pharmacological Research - Year 2015, Vol 5, Issue 11
Abstract
Objective: To study the protective effect of Lonicera Japonica Alcoholic Extract (LJALE) on Diabetes Mellitus II (DM) and associated vascular complications. Methods: Induction of Diabetes Mellitus II with 35 mg / kg STZ-HFD leads to excessive level of 11?-HSD1 enzyme. It has been found that flower buds of Lonicera Japonica (LJ) has also been traditionally indicated for treatment of diabetes. Chlorogenic Acid (CA) is a major bioactive component in the flower buds of LJ has received more attention because of its 11?-HSD1 inhibitory action.11?-HSD1 regulates glucocorticoid action at the pre-receptor stage by converting cortisone to cortisol. Elevated glucocorticoids are a key risk factor for metabolic diseases. LJALE was prepared with help of Microwave Assisted Extraction (MAE) method. STZ-HFD-induced diabetic rats were treated with LJALE (200 mg/kg, 500 mg/kg) and Metformin (50 mg/kg). It was given for 4 weeks. Result: LJALE treated Diabetic rats showed significant decreased in blood glucose levels, plasma insulin, serum cortisol as well significant increased hepatic glycogen, 11?-HSD1 index compare to diabetic control rats. LJALE (500 mg/kg) treatment showed the return of islets close to good vascular pattern. LJALE treatment restored endothelium dysfunction. Conclusions: From all results it is reasonable to conclude that LJALE (500 mg/kg) may be used in treatment of diabetes and diabetes associated vascular dysfunction.
Authors and Affiliations
Chiragkumar Amrutlal Prajapati, Falguni D Majmudar
Keywords
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- EP ID EP435430
- DOI 10.7439/ijpr.v5i11.2782
- Views 64
- Downloads 0
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