Psoraleae induces hepatotoxicity by affecting bile acid balance
Journal Title: Toxicology Communications - Year 2021, Vol 3, Issue 1
Abstract
Background: Buguzhi (Psoraleae fructus), the seed of Psoralea corylifolia Linn, is used to treat osteoporosis, nephritis, vitiligo and other diseases. However, long-term routine or overdose of Psoraleae fructus may lead to hepatotoxicity and become a major obstacle of its clinical usage. Psoralen was a key active component of Psoraleae fructus, and a main cause of Psoraleae fructus toxicity. This research was to investigate the hepatotoxicity of psoralen and whether it’s related with bile acid imbalance. Methods: C57BL/6 mice were randomly divided into 4 groups (n = 10). Psoralen (20 mg/kg, 40 mg/kg and 80 mg/kg) was administrated intragastrically once every day and control group with equivalent water until 4 weeks. Results: The results showed that psoralen caused an increase in liver coefficient and the injury of hepatocytes microstructure of mice. It also inhibited cell viability of HepG2 cells. Mice treated with psoralen exerted liver total bile acid increased while serum total bile acid decreased, which indicated that psoralen-induced liver injury may partly associate with cholestasis. For further study of liver transporters, high dose of psoralen inhibited the expression of some important hepatic efflux transporters (including BSEP, p-gp and ABCG5) in vivo and in vitro. Conclusion: We provide evidence for the first time that psoralen may induce cholestatic hepatotoxicity for the bile acid retention by inhibition on bile acid export pumps.
Authors and Affiliations
Wei-Ling Pu, Bin Yu, An-Hong Wang, Ya-Nan Bi, Hong Shi, Kun Zhou
Keywords
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- EP ID EP692820
- DOI 10.12032/ATR20210202
- Views 139
- Downloads 0
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