The efficacy and safety of Shuxuening injection combined with western medicine in vascular dementia treatment: a meta-analysis
Journal Title: Toxicology Communications - Year 2021, Vol 3, Issue 2
Abstract
Background: To systematically evaluate the efficacy and safety of the Chinese patent medicine Shuxuening injection combined with western medicine in vascular dementia treatment. Methods: Randomized controlled trials of the Chinese patent medicine Shuxuening injection in vascular dementia treatment is searched in the databases of CNKI, Wanfang, VIP, CBM, PubMed, The Cochrane Library, Embase and Web of Science from the establishment time to December 2020. After screen the literature, extract the data and evaluate the bias risk of studies included; tRevMan5.3 was used for met-analysis. Results: Nine randomized controlled trials including 932 patients were included. The results of meta-analysis included: (1) the total effective rate (RR = 1.27, 95% CI (1.18, 1.36), P < 0.00001); (2) MMSE score (MD = 4.78, 95% CI (1.75, 7.80), P = 0.002); (3) ADL score (MD = 8.87, 95% CI (6.70, 11.05), P < 0.00001); (4) NIHSS score (MD = −6.60, 95% CI (−7.04, −6.16). P < 0.00001). The results of meta-analysis of the test group are better than those in the control group. Conclusion: The Chinese patent medicine Shuxuening injection combined with conventional western medicine has showed some advantages in the total effective rate, MMSE score, ADL score, NIHSS score than conventional western medicine without more side effects in vascular dementia treatment. More randomized, double-blind, large sample clinical studies are needed to confirm the above conclusions.
Authors and Affiliations
Zhong-Qing Dou, Yi-Hua Fan, Hui-Xin Chen, Xin-Rong Wang, Jin-Rui Wei, Xin-Ju Li
Keywords
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- EP ID EP694560
- DOI 10.12032/ATR20210504
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