QUALITATIVE AND QUANTITATIVE DETERMINATION OF SECONDARY METABOLITES AND ANTIOXIDANT POTENTIAL OF FICUS BENGHALENSIS LINN SEED
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: To evaluate the phytochemical constituents and the antioxidant activity of ethanolic extract of Ficus benghalensis seed locally prescribed as a diet for peptic ulcer.Methods: Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics, flavonoids and tannins were determined by the well-known test protocol available in the literature. The antioxidant and free radical scavenging activity of ethanolic extract of the plant was assessed against DPPH, nitric oxide, lipid peroxidation and reducing power assay using standard protocols.Results: Phytochemical analysis revealed the presence of phenols, flavones, tannins, carbohydrates, saponins, alkaloids, cardiac glycosides, steroids, quinones, terpenoids and coumarins. The total tannin content of the ethanolic seed extract was high (127.121.508 TEg), followed by phenolics (80.461.868 GEg) and flavonoids (39.231.205 QEg). The activities of plant extract against DPPH, nitric oxide and lipid peroxidation were concentration dependent with IC50 values of 446.9, 596.0 and 557.0 µg respectively. The reducing ability of F. benghalensis was found to be 418.34 at 1000 μg.Conclusion: Our findings provide evidence that the crude extract of Ficus benghalensis is a potential source of natural antioxidants, and this justifies its use in folkloric medicine.Â
Authors and Affiliations
Vimala Govindan, Francis Gricilda Shoba
Keywords
Related Articles
- EP ID EP578533
- DOI -
- Views 78
- Downloads 0
ELICITATION OF THERAPEUTIC POTENTIAL AND OXIDATIVE STRESS ASSESSMENT OF FENUGREEK SPROUTS UNDER UV IRRADIATION
Objective: To evaluate the effect of ultraviolet (UV) radiation on the therapeutical and oxidative stress status of fenugreek seedlings during the post-germination phase.Methods: The seeds of Trigonella foenum-graecum L....
STREPTOMYCES CELLULOSAE VJDS-1, A PROMISING SOURCE FOR POTENTIAL BIOACTIVE COMPOUNDS
Objectives: The aim of the present study was to isolate, identify and analyze the phylogenetic characteristics of the potent actinobacterial strain VJDS-1 with antagonistic activities isolated from Mangrove ecosystems of...
FORMULATION AND EVALUATION OF OXICONAZOLE MUCOADHESIVE NANOEMULSION BASED GEL FOR TREATMENT OF FUNGAL VAGINAL INFECTION
Objective: The aim of the present study was to formulate and evaluate nanoemulsion-based gel of oxiconazole nitrate (OXZ) for the treatment of vaginal infection.Methods: The solubility of Oxiconazole nitrate in various o...
CANCER NANOTECHNOLOGY: NANOPARTICULATE DRUG DELIVERY FOR THE TREATEMENT OF CANCER
In 21st century scientist all around are trying to formulate the new drug delivery with better efficacy and effectiveness to treat cancer. So their focus has been shifted toward the Nano based drug delivery system becaus...
EFFICACY OF TRIDHAM AND 1,2,3,4,6-PENTA-O-GALLOYL-β-D-GLUCOSE IN REVERSING LIPID PEROXIDATION LEVELS AND MITOCHONDRIAL ANTIOXIDANT STATUS IN 7,12-DIMETHYLBENZENEANTHRACENE (DMBA) INDUCED BREAST CANCER IN SPRAGUE-DAWLEY RATS
Objective: To determine the effect of Tridham (TD) and 1,2,3,4,6-penta-O-galloyl-β-d-glucose(PGG) on lipid peroxidation levels and mitochondrial antioxidants status in experimental mammary carcinoma.Methods: Elaecoarpus...