Random Urine Protein/Creatinine Ratio as a Predictor of Significant Proteinuria in Preeclampsia

Journal Title: Pan Asian Journal of Obstetrics & Gynecology - Year 2018, Vol 1, Issue 2

Abstract

Background: Proteinuria is a significant marker of preeclampsia. Urinary protein in a 24-hour urine collection is conventionally considered as the standard for detection of proteinuria. However, it is tedious and is associated with collection errors. The role of urine protein/ creatinine ratio (UPCR) in a random urine sample is being proposed as an alternative. Aims: To compare accuracy of dipstick and random UPCR vis-a-vis 24-hour urine protein for prediction of significant proteinuria in preeclampsia. Study Design: Prospective cross-sectional study. Methods/Materials: Two hundred pregnant women with gestational age more than 20 weeks of pregnancy with blood pressure ≥ 140/90 mm Hg were recruited in the study. For each patient, the proteinuria was estimated by dipstick, random UPCR and 24-hour urine protein. Considering the 24-hour urinary protein analysis to be gold standard, the results of the other two methods were compared for their diagnostic accuracy. Data was compared by using Pearson’s correlation coefficient (r). Receiver operating characteristic (ROC) curve was plotted for spot UPCR value for detecting significant proteinuria (≥ 300 mg/day). Results: The quantification of proteinuria by spot UPCR strongly correlated with 24-hour urinary protein (r = 0.857 with p value < 0.001). The most discriminant value for the same was 1.16. Area under ROC curve for spot UPCR (0.96) was significantly more than that for dipstick urine analysis (0.766), thus making spot UPCR more accurate predictor of significant proteinuria. Spot UPCR also came out to be better predictor of adverse feto-maternal outcome. Conclusion: Spot UPCR is an appropriate rapid alternative method for quantification of proteinuria in preeclampsia. It can also be used as an adjunct to predict the risk of adverse feto-maternal outcome.

Authors and Affiliations

Ankita Nigam

Keywords

Related Articles

Acardiac Anceps Twin: Case Report

Acardiac twin is an anomaly, which rarely occurs in monochorionic twin pregnancies. The normal twin is also called as pump twin as it pumps blood to the acardiac twin. Acardiac twin lives like a parasite with normal twin...

Pigmentation after Iron Polymaltose Infusion: Learning Points

A 40 year multiparous female presented with menorrhagia and severe anemia. She had been diagnosed as a case of fibroid uterus with menorrhagia with iron deficiency anemia. She received 1000 mg of iron polymaltose complex...

Tdap Vaccination during Pregnancy: Rationale and Recommendations

Pertussis remains a major health problem in developed as well as developing countries. Mortality due to pertussis occur almost exclusively in the early infantile life i.e less than 3 months of age. Maternal immunization...

Postpartum Depression—An Overview

Peripartum is the time when a female is most vulnerable to develop mental illness. Postpartum depression (PPD) is the most common psychiatric morbidity seen during this period. Prevalence of PPD is higher in developing c...

Random Urine Protein/Creatinine Ratio as a Predictor of Significant Proteinuria in Preeclampsia

Background: Proteinuria is a significant marker of preeclampsia. Urinary protein in a 24-hour urine collection is conventionally considered as the standard for detection of proteinuria. However, it is tedious and is asso...

Download PDF file
  • EP ID EP546201
  • DOI -
  • Views 141
  • Downloads 0

How To Cite

Ankita Nigam (2018). Random Urine Protein/Creatinine Ratio as a Predictor of Significant Proteinuria in Preeclampsia. Pan Asian Journal of Obstetrics & Gynecology, 1(2), 54-58. https://europub.co.uk/articles/-A-546201