Randomized Study of Oral Misoprostol for Cervical Ripening before Intracavitary Brachytherapy for Carcinoma Uterine Cervix
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 2
Abstract
Intracavitary brachytherapy forms an integral part of treatment of carcinoma cervix and the complications arising out of the procedure are partly related to the difficulties in cervical dilatation. This study aims to evaluate the efficacy of oral misoprostol in facilitating this transcervical procedure as a part of intracavitary brachytherapy and reduce the complications of the procedure. A total of 100 patients of carcinoma cervix stage II and III were included in the study who underwent external beam radiotherapy followed by intracavitary brachytherapy. These were randomly assigned to the study group and the placebo group. Study group received 400 microgram of misoprostol orally, three hours before the procedure. The procedure was evaluated for the amount of bleeding, size of the initial hegar dilator, grading of the procedure as easy, moderate or difficult, subjective perception of rigidity of cervix and subjective difficulty level of tandem insertion. With regard to bleeding, no significant difference was found in both the arms (Chi square test- 0.285). Other parameters measured like ease of dilation and the average no. of hegar dilator used were found to be insignificant. Administration of misoprostol 400 micrograms for cervical ripening for tandem application facilitates the transcervical procedure, increases tolerability and decreases the complications of procedure in this study.
Authors and Affiliations
Mridul Anand, Ankita Parikh, Sonal Patel, Suryanarayan Shah
Keywords
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