Rare Mixed Thyroid Cancers- Two Case Reports
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Introduction: Thyroid cancers constitute 0.5%- 1% of all cancers of which differentiated cancers are most common. Mixed thyroid carcinomas are rare entities comprising only 0.5% of thyroid cancers. These tumours pose challenges in diagnosis by fine needle aspiration cytology. Case Reports: Here, we present two rare cases of these mixed thyroid carcinomas. First is a 21 year old female diagnosed as medullary thyroid carcinoma on Fine Needle Aspiration Cytology (FNAC).She underwent definitive surgical treatment. Final histopathology revealed diagnosis of a nodular tumour with mixed features predominantly medullary carcinoma with areas of follicular carcinoma, confirmed on immunohistochemistry. Second report is of a 45 year old female diagnosed as medullary thyroid carcinoma on fine needle aspiration cytology (FNAC). Definitive surgical treatment was performed. Histopathology showed a mixed tumour with medullary and papillary components as confirmed on immunohistochemistry. Conclusion: The knowledge of these rare carcinomas is important in avoiding a dilemma in management. Recognition of these mixed tumours are difficult by FNAC and the recognition of medullary component is essential for definitive treatment. We re-emphasize the importance of immune-histochemistry in arriving at an accurate diagnosis.
Authors and Affiliations
Dr. Nitya Subramanian
Keywords
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