A Study on Adenosine Deaminase (ADA) Activity in Tubercular Serositis: As A Diagnostic Tool
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
Background: Adenosine deaminase has been proposed to be a useful surrogate marker for tuberculosis in pleural, pericardial and peritoneal fluids. Studies have confirmed high sensitivity and specificity of Adenosine deaminase for early diagnosis of extra pulmonary tuberculosis. Aim: To assess the diagnostic level of ADA in tubercular serosal effusion and to determine its sensitivity and specificity. Methods: The study was carried out on 120 patients suffering from serosal effusion (50 pleural, 50 peritoneal, and 20 cases of pericardial effusion). Detailed clinical history, physical examination and routine and relevant investigation of all patients including ADA estimation by enzymatic method was done. Results: ADA Level in tuberculous pleural effusion ranged from 45-160 U/L with a mean level of 100U/L and sensitivity and specificity of 100% (p<0.001, highly significant). ADA level in tuberculous peritoneal effusion ranged from 35-135 U/L with a mean level of 92U/L and sensitivity and specificity of 100% and 95% respectively (p<0.001, highly significant). ADA level in tubercular pericardial effusion ranged from 63-117 U/L with a mean level of 90U/L and sensitivity and specificity of 100% and 83.3% respectively (p<0.005, very significant). In toto serosal fluid ADA level estimation offers high degree of sensitivity and specificity of about 100% and 94.6% respectively, Conclusion: ADA was found positive with a mean value of 100U/L, 92U/L and 90 U/L in tubercular pleural, peritoneal and pericardial effusion respectively with overall 100% sensitivity and 94.6% specificity and cutoff value of 40 U/L.
Authors and Affiliations
Dr K Sreenivasa Rao
Keywords
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