Re-Engraftment of Prior Cord Blood Graft in a Patient with Relapsed/Refractory Acute Myeloid Leukaemia following Haploidentical Transplantation
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2015, Vol 3, Issue 7
Abstract
We report the case of a 32-year-old man with poor risk acute myeloid leukemia (AML) who received transplantation of an UCB graft following myeloablative conditioning but unfortunately relapsed after one year with complete loss of donor chimerism. As this patient did not have an HLA - matched sibling donor or a volunteer MUD, he went on to receive a second transplant with haploidentical CD34 cells from his mother following a non-myeloablative conditioning. After initial engraftment with the haploidentical donor cells, the patient became progressively pancytopenic and chimerism analysis revealed decreased level of cells derived from the haploidentical graft. However, there was a concurrent increasing ratio of the UCB derived cells from the first transplant. The patient had eventual recovery and stabilization of his full blood count and repeat chimerism analysis demonstrated successful re-engraftment with the previous UCB graft. To the best of our knowledge, no such similar cases have been reported in the literature. Thus, cord blood cells from a prior transplant could remain present in small quantities at the phase ofleukemia relapse and re-emerge to establish long term hematopoiesis even after graft failure from a subsequent haploidentical transplant.
Authors and Affiliations
Lim Wei Inng Francesca Lorraine
Keywords
Related Articles
- EP ID EP197102
- DOI 10.19070/2328- 3548-1500021
- Views 102
- Downloads 0
Effect of Population Doublings on Differentiation Capacity of Human Adipose-Derived Stem Cells: Establishing Standard Guidelines for Clinical Translational Applications
Human adipose-derived stem cells (ASCs) are providing promise in clinical soft tissue replacement and repair. This study investigated the effect of multiple population doublings (PD) on ASCs growth rates and cell specifi...
Central Pontine Myelinolysis Associated with Cyclosporine in a Patient with NK Cell Leukaemia after Hematopoietic Stem Cell Transplantation
Central pontine myelinolysis (CPM) has been described as a rare complication of liver transplantation. Cases in allogeneic hematopoietic stem cell transplant are less reported. We present a patient with NK cell leukaemia...
ISW for the Treatment of Adult Angle Class I Crowding with Acceptable Lateral Profile Case
This article describes a 34-year-old adult female with chief complaint of poor dental alignment. She presented with Angle Class I crowding with acceptable lateral profile and had been treated with a non-extraction approa...
Living Kidney Donation: Evolution of Strategies
Living Kidney Donation: Evolution of Strategies
Factors Associated with Umbilical Cord Blood Derived Mononuclear Cells Banking in Morocco: A Preliminary Study
Umbilical cord blood (UCB) is commonly used as the main heamatopoietic stem cell (HSC) source for allogeneic transplantation. Immediately available when compared to bone marrow (BM), UCB is now widely processed and store...