RECENT TRENDS IN USAGE OF POLYMERS IN THE FORMULATION OF DERMATOLOGICAL GELS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Topical preparations can be applied directly to an external body surface by spreading, rubbing, and spraying. The topical route of administration has been utilized either to produce local effect for treating skin disorder or to produce systemic drug effects. Within the major group of semisolid preparations, the use of transparent gels has expanded both in cosmetics and in pharmaceutical preparations. Gels often provide a faster release of drug substance, independent of the water solubility of the drug, as compared to creams and ointments. They are highly biocompatible with a lower risk of inflammation or adverse reactions, easily applied and do not need to be removed. Gels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removed, emollient, non-staining, and compatible with several excipients and water soluble or miscile. Dosage form selection should include those delivery systems that are noncomedogenic. Gels tend to be most effective as they have faster absorption than creams. Gels containing only water tend to be slow to dry; so the addition of ethyl or isopropyl alcohol to the gel hastens their drying to a film. But some patients may need the less drying lotions or creams for dry or sensitive skin or for use during dry winter weather.
Authors and Affiliations
Shaik Arif Bhasha, Syed Abdul Khalid, S. Duraivel, Debjit Bhowmik, K. P. Samapth
Keywords
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