Regression of Kaposi’s Sarcoma after Anti- Tuberculous Therapy In A HIV-Negative Case With Disseminated Tuberculosis
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 4, Issue 4
Abstract
Although Kaposi sarcoma occurs in immune compromised patients, including Human Immunodeficiency Virus (HIV) infection patients, Kaposi sarcoma associated with disseminated tuberculosis has rarely been reported on. We present a case of Kaposi sarcoma that developed in an HIV-negative patient with disseminated tuberculosis. The Kaposi sarcoma completely regressed with antituberculous therapy without the institution of any chemotherapy, radiotherapy or surgery. The patient remained disease-free after a long-term follow-up over five years. This 83 year-old male without systemic disease history, was hospitalized due to fever, cough, dyspnea, and swelling of right knee and right lower leg for one week. After admission, on October 11, 2008, Chest X-ray revealed fibrocalcified lesions over right lung with pleural effusion, and pneumonia subsequently progressed over the right lower lobe and left upper lobe within 2 weeks. Acidfast bacilli from the sputum was found and pulmonary tuberculosis (TB) was diagnosed. We also noted an ulcer of his upper lip, and the biopsy showed granulomatous tissue with ulcerative surface, many horse-shoe shaped multinucleated giant cells and positive acid-fast bacilli. Synovial fluid aspirated from the right knee examined for TB-PCR (polymerase chain reaction) turned out to be positive. We initiated anti-TB regimen of rifater (rifampicin 120mg, isoniazid 80mg, pyrazinamide 250mg) at 4 tablets daily from October 15, 2008, and then 2 months later we shifted it to rifinah (rifampicin300 mg, isoniazid 150mg) at 2 tablets daily. However, the sputum and synovial fluid culture showed no growth of tuberculosis. At the same time, multiple indurated, painless, violaceous, nonpruritic skin lesions occurred on both feet and legs (Figure 1a), which was confirmed to be Kaposi’s sarcoma (KS) via the histopathologic findings from the skin biopsy; the acid-fast stain failed to reveal any microorganism. The patient did not notice this skin lesion before and the patient’s ELISA test of HIV showed negative. He had normal CD4/CD8 ratio (1.15) and normal absolute CD4 count Cytomegalovirus IgG, VZV and HSV IgG showed positive but HBsAg, anti-HCV Ab and HTLV 1/2 (human T-lymphotropic virus) showed negative result. Chemotherapy was not performed because of his initially poor general health condition. The KS lesions worsened after two months of TB treatment (Figure 1b), but unexpectedly regressed thereafter. A one-year treatment course for disseminated TB was completed. The KS lesions completely subsided and no relapse was detected after the 5- year regular follow-up (Figure 1c). His anemia was also improved with an increase of hemoglobin (Hb) from 8.4 g/dl to 13.3 g/dL (Figure 1c). The etiology of Kaposi’s sarcoma is complex and multifactorial. Reported epidemiologic data has revealed that KS has been seen in certain diseases, such as HIV infection, cytomegalovirus, hepatitis B virus, HTLV-1 (Human T-lymphotropic virus type 1), immune suppressed individuals [1-5], lymphoma [6], organ-transplanted patients [7,8], patients receiving long-term immunosuppressive therapy [9], but KS has rarely been reported in tuberculosis patients. HHV-8 has been strongly associated with a viral cofactor in the pathogenesis of KS [10]. And whereas there were reports of KS with tuberculosis in HIV-infected patients, there were only four cases of KS related to tuberculosis infections in HIV negative patients found in the literature since 1988 [11-14]. One case developed rapid-deteriorating orificial tuberculosis concomitant with Kaposi’s sarcoma and resulted in a fatal outcome [13]. Another case had multiple-drug resistant tuberculosis with a 2-year course of anti-tuberculosis treatment, and his KS regressed after 8 weeks’ treatment of anti-tuberculosis, and for this reason, KS secondary to pulmonary tuberculosis was postulated [14]. In our case, we gave him 1 year of anti-TB treatment because of his disseminated tuberculosis involving the oral cavity and joint, and his KS regressed after anti-TB therapy without chemotherapy, radiotherapy or surgery. To our knowledge, this is the first case with TB of the oral cavity and right knee, with KS that survived over 5 years without chemotherapy and responded to anti-TB drug therapy only.
Authors and Affiliations
Ko Chang, Wei-Ru Lin, Po-Chih Chen, Jih-Jin Tsai
Keywords
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- EP ID EP590942
- DOI 10.26717/BJSTR.2018.04.001084
- Views 127
- Downloads 0
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