RELATION OF ANTIOXIDANT STATUS AND LIPOPROTEIN (a) LEVEL IN MYOCARDIAL INFARCTION PATIENTS : A CLINICAL STUDY TO EVALUATE THE ANTIOXIDANT/ LIPOPROTEIN (a) RATIO AS A NOVEL PARAMETER TO INDICATE CARDIOVASCULAR ACCIDENT
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 2
Abstract
Lipoprotein (a), a prominent marker of cardiovascular accident, was first described by Berg in 1963(3). Lipoprotein (a) [Lp(a)] has been considered as one of the distinguished signature in myocardial infarction and for many years.1. Owing to incomplete scientific evidence in clinical practice, screening for and treatment of high Lp(a) levels is primarily essential . On the other hand free radicals, now shown to be one of the underlying causes in neurological and immunological diseases, possess tremendous affinity to pair with electrons to form couples. These high velocity reactions have been shown to be the major mechanism behind the harmful effect of free radicals. The present study aims to correlate the antioxidant status ,which has been shown to be associated with kidney, heart and lung diseases, with lipoprotein (a) or Lp (a), The free radicals, basically species with unpaired electrons have been found to be of the causative agents for shifting of equilibrium of pro-oxidant antioxidant balance. Aims and Objectives: Aim of our study is 1.To determine the level of Lp (a) and antioxidant status of patients viz. the antioxidant in vivo parameters like catalase [CAT], superoxide dismutase[SOD] and reduced sulfhydryl group[GSH] 2. To find out the significance of relation between parameters of antioxidant and Lipoprotein (a) level among the patients of cardiovascular accident 3. To compare the Lipoprotein (a) and antioxidant status 4. To find out the significance of Lipoprotein (a) level antioxidant status and correlate the two parameters in acute myocardial infarction [AMI] patients.
Authors and Affiliations
Biswajit Majumdar| Reader and Head, Department of Biochemistry, Awadh Dental College and Hospital, Kolhan University, Tapan Debnath| Associate Professor, Department of Biochemistry, Tripura Medical College, Sankar Roy| Associate Professor, Department of Biochemistry, Tripura Medical College, Avik Chakraborty| Professor, Department of Medicine, Tripura Medical College and DR. BRAM Teaching Hospital, Hapania, Agartala, Tripura., Partha Sarathi PaL| Assistant Professor, Department of Biochemistry, Tripura Medical College, Mohan Chandra Mondal| Professor and Head, Department of Biochemistry, Tripura Medical College
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