Relationship of inflammatory markers with metabolic and anthropometric variables in obese individuals
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 22, Issue 1
Abstract
Introduction: It is recognized that obesity is associated with a chronic low-grade inflammation and activation of immune system. Serum sialic acid and C-reactive protein (CRP) are markers of inflammation. Aims and Objectives: The aim of our study was to evaluate the serum concentrations of high-sensitivity CRP (hs-CRP) and total sialic acid and the conventional cardiovascular risk factors like lipid parameters, blood pressure and blood glucose in obese subjects and to find the possible correlations between these factors in such patients. Methodology: We studied 50 obese subjects and 50 non obese controls, between the age group of 20 and 60 years. Lipid profile, hs- CRP, total sialic acid, fasting blood sugar, body mass index and waist hip ratio were determined in the two groups. Quantitative data of the two groups were expressed as mean and standard deviation and compared by unpaired ‘t’ test. Association between hs - CRP and total sialic acid with the various metabolic and anthropometric variables was assessed by Pearson correlation. A ‘p’ value less than 0.05 is considered significant. Results: Serum total sialic acid and lipid levels were significantly elevated in the obese group compared to the non-obese group (p<0.05). There was significant correlation between hs - CRP and total sialic acid with body mass index, waist hip ratio blood pressure and lipid parameters (p<0.05). Conclusions: Our findings suggest that in obesity, there is an association between serum sialic acid and hs- CRP levels with obesity indices, and various conventional cardiovascular risk factors like lipid profile, increased BP and blood sugar, thus contributing to cardiovascular risk.
Authors and Affiliations
Bindu Gopinathan Nair, Saleena Prameela Chinnaiah Rajadas
Keywords
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