Relationship of mean platelet volume to an acute ischemic stroke
Journal Title: Ege Tıp Dergisi - Year 2014, Vol 53, Issue 1
Abstract
Aim: Platelet activation has a major role to play in the development of ischemic cerebrovascular disease. Mean platelet volume (MPV) is reported to be a good indicator of platelet activity. In this study, we aimed to determine the position of MPV in the pathogenesis of ischemic strokes. Materials and Methods: This study compared MPV values in 110 patients who were hospitalized with the diagnosis of the first and recurrent stroke with the risk factors and stroke subtypes, and 58 control patients who were age and sex matched to patients. MPV parameters are measured in the acute period of the stroke and 24 hours later. We investigated the relationship between the mean platelet volume and risk factors, stroke subtypes, haematological and biochemical parameters, white blood cell, platelet, cholesterol, triglycerides, LDL cholesterol, glucose, erythrocyte sedimentation ratio (ESR), partial thromboplastin time (aPTT), and C-reactive protein (CRP). Results: The MPV parameter was found to be higher in the case group than the control group (p <0.001). In the case group, we found a weak significant negative correlation between platelet count (r = -0.20 p <0.05) and MPV parameter measured upon admission in the case group. Conclusion: In acute stroke patients, the MPV value was significantly higher compared to the acute stroke patients within the control group, so that a high MPV value may be one of the factors that play a role in the development of ischemic strokes and cerebrovascular disease, suggesting a rise in a secondary phenomenon.
Authors and Affiliations
Ş Deveci, A Çelebi, S Aşkın, A E Gürsoy, M Kolukısa
Keywords
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