RELEVANCE OF EPIGENOMICS IN THE MANAGEMENT OF CANCER
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 4
Abstract
The recognizable proof of all epigenetic adjustments involved in gene expression is the succeeding stage for an improved comprehension of human biology in both typical and obsessive states. This field is implied as Epigenomics, and it is outlined as epigenetic changes (i.e., DNA methylation, histone modification and regulation by noncoding RNAs, for example microRNAs) on a genomic scale as opposed to a solitary gene. Epigenetics tweak the structure of the chromatin, subsequently influencing the translation of genes in the genome. Distinctive studies have recently distinguished changes in epigenetic changes in a couple of genes in particular pathways in cancers. In view of these epigenetic changes, drugs against distinctive sorts of tumors were produced, which fundamentally target epimutations in the genome. Examples incorporate DNA methylation inhibitors, histone modification inhibitors, and small molecules that target chromatin-renovating proteins. Then again, these medications are not particular, and reactions are a major issue; along these lines, new DNA sequencing innovations joined with Epigenomics tool have the possibility to recognize novel biomarkers and better molecular focuses to treat Cancer. The motivation behind this review is to talk over current and rising Epigenomics tools and to address how these new innovations might affect time to come of cancer management.
Authors and Affiliations
Pramod Khatri| Genetics Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India
Keywords
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