RELEVANCE OF EPIGENOMICS IN THE MANAGEMENT OF CANCER
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 4
Abstract
The recognizable proof of all epigenetic adjustments involved in gene expression is the succeeding stage for an improved comprehension of human biology in both typical and obsessive states. This field is implied as Epigenomics, and it is outlined as epigenetic changes (i.e., DNA methylation, histone modification and regulation by noncoding RNAs, for example microRNAs) on a genomic scale as opposed to a solitary gene. Epigenetics tweak the structure of the chromatin, subsequently influencing the translation of genes in the genome. Distinctive studies have recently distinguished changes in epigenetic changes in a couple of genes in particular pathways in cancers. In view of these epigenetic changes, drugs against distinctive sorts of tumors were produced, which fundamentally target epimutations in the genome. Examples incorporate DNA methylation inhibitors, histone modification inhibitors, and small molecules that target chromatin-renovating proteins. Then again, these medications are not particular, and reactions are a major issue; along these lines, new DNA sequencing innovations joined with Epigenomics tool have the possibility to recognize novel biomarkers and better molecular focuses to treat Cancer. The motivation behind this review is to talk over current and rising Epigenomics tools and to address how these new innovations might affect time to come of cancer management.
Authors and Affiliations
Pramod Khatri| Genetics Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India
STUDY ON MATRIX METALLOPROTEINASES IN DIABETIC FOOT ULCER DISEASE
The aim of this study is to compare the level of matrix metalloproteinases in diabetic and non-diabetic foot ulcer disease patient’s plasma and tissue sample. Design: Cross-sectional study. Patients: We studied a group o...
Dream: from Phenomenology to Neurophysiology
Dream is commonly used to express an unattainable ideal or a very deep and strong desire. Neurophysiological correlation of dreaming are still unclear and many questions remain unresolved, i.e. whether the images in dr...
A STUDY OF FORCED VITAL CAPACITY IN TYPE 2 DIABETES MELLITUS PATIENTS IN CHITRADURGA CITY, KARNATAKA
Diabetes Mellitus (DM) is a metabolic disorder precipitating micro vascular, macro vascular complications and peripheral vascular diseases. Less has been known about the after effects of diabetes on lungs. So this work...
THE ASSOCIATION BETWEEN OSTEOPOROSIS AND CHRONIC PERIODONTITIS: A CASE-CONTROL STUDY
Background & Objectives: Periodontitis and osteoporosis affects millions of people around the world resulting in significant amount of morbidity. This cross-sectional study aims to determine the association between osteo...
Evaluation of Anti-Acne Property of Poly Herbal Formulation
Acne vulgaris is an extremely common skin disorder that affects virtually all individuals at least once during life. Herbal medications are considered safer than allopathic medicines as allopathic medicines are associate...