RELEVANCE OF EPIGENOMICS IN THE MANAGEMENT OF CANCER
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 4
Abstract
The recognizable proof of all epigenetic adjustments involved in gene expression is the succeeding stage for an improved comprehension of human biology in both typical and obsessive states. This field is implied as Epigenomics, and it is outlined as epigenetic changes (i.e., DNA methylation, histone modification and regulation by noncoding RNAs, for example microRNAs) on a genomic scale as opposed to a solitary gene. Epigenetics tweak the structure of the chromatin, subsequently influencing the translation of genes in the genome. Distinctive studies have recently distinguished changes in epigenetic changes in a couple of genes in particular pathways in cancers. In view of these epigenetic changes, drugs against distinctive sorts of tumors were produced, which fundamentally target epimutations in the genome. Examples incorporate DNA methylation inhibitors, histone modification inhibitors, and small molecules that target chromatin-renovating proteins. Then again, these medications are not particular, and reactions are a major issue; along these lines, new DNA sequencing innovations joined with Epigenomics tool have the possibility to recognize novel biomarkers and better molecular focuses to treat Cancer. The motivation behind this review is to talk over current and rising Epigenomics tools and to address how these new innovations might affect time to come of cancer management.
Authors and Affiliations
Pramod Khatri| Genetics Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India
Design and in vitro Evaluation of Mucoadhesive Mini Matrices of Losartan Potassium
Mini matrices containing Losartan potassium as a model drug were prepared by extrusion method using Hydroxy propyl methyl cellulose as matrix materials with or without xanthan gum and carbopol, and combination of xanthan...
Synthesis and antimicrobial evaluation of N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl benzamide derivatives
Thiazole is five membered ring system with one nitrogen and one sulphur atom. Some thiazole derivatives were synthesized and confirmed their antimicrobial activity. Many researchers reported about thiazole & their deriva...
ELECTROCHEMICAL PEROXIDASE SENSOR BASED ON MAGNESIUM OXIDE-CHITOSAN NANOBIOCOMPOSITE FILM
Nanoparticles play a major role in development of new hybrid composites for various engineering applications. A simple and novel amperometric biosensor for hydrogen peroxide detection is proposed. It is based on the immo...
FREQUENCY OF HEPATITIS E VIRUS AMONG RENAL TRANSPLANT RECIPIENTS PATIENTS IN KHARTOUM - SUDAN
Background: Renal transplant recipients are known to be susceptible to viral infections, with more severe clinical presentations compared to healthy persons. Hepatitis E virus (HEV) is generally a self-limited disease,...
BENEFICIAL ROLE OF HERBAL HEPATOPROTECTANTS: A NOVEL APPROACH TO PREVENT HEPATOTOXICITY DUE TO ANTITUBERCULOSIS TREATMENT
The first line antituberculosis drugs, isoniazid, rifampicin and pyrazinamide continue to be the effective in the treatment of tuberculosis; however, their use is associated with toxic reactions in tissues, particularly...