Removal of the Bad Effects of D-Galactosamine on Blood Lipids of Male Wistar Rats By Black and Green Tea Consumption
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
There is an increase in overall health awareness in Saudi Arabia due to a rising rate of diseases such as diabetes and heart diseases in addition to obesity. Thus, Saudi Ministry of Health initiates many programs to improve their eating and drinking habitats. Black and green tea were used as healthy drinks to alternative highcalorie, sugary drinks. The effect of black and green tea consumption on serum lipid and glucose levels in untreated and galactosamine treated male Wistar rats was detected. In this study, male Wistar rats (90) were divided to 3 groups, the first one, 30 rats that drank water, the second group, 30 rats drank 2% green tea and the third group is 30 rats that drank 2% black tea for 4 weeks. Each rat group was separated into two subgroups, the first intraperitoneally injected with D-Galactosamine (GalN) and the second group was injected with saline solution. Analysis of blood indicated that serum triglyceride levels (one of the hepatotoxic parameters) showed a marked reduction in response to GalN administration by 29.21%, 36.70% and 26.94% in control, green tea and black tea groups, respectively, as compared to those untreated animals. Moreover, in the comparison between the groups of treated animals, rats drinking green tea recorded the lowest serum triglyceride level as compared to rats consuming either water or black tea. Black tea consuming groups recorded 56.73% reduction in serum total lipids as compared to the control group. Regarding serum glucose level, treated rats drinking tea (green or black) showed a significant reduction as compared to treated rats drinking water. Serum total cholesterol levels were significantly elevated in response to GalN injection in rats drinking black tea by 45.22% as compared to untreated ones, while a small and not significant increase was recorded in green tea group.
Authors and Affiliations
Madeha N. Al-seeni, Abeer A. Banjabi, Karima S. Mohamed
Keywords
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- EP ID EP387272
- DOI 10.9790/3008-120101123132
- Views 52
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