Repair of segmental bone defect using calcium phosphate granules and allogeneic bone matrix gelatin mixture in rabbits
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 6, Issue 2
Abstract
Several methods are used to enhance bone repair and new bone formation. Bone matrix gelatin is recently introduced and calcium phosphate has gained importance in orthopaedics as repair materials for bone defects. The objective of this study was to evaluate of effects of a mixture of calcium phosphate granules and allogeneic bone matrix gelatin on bone repair in rabbit. 30 male rabbits were divided into three groups. After induction of general anesthesia, a segmental bone defect of 5 mm in length was created in the middle of the left radius shaft. In control group defect was left untreated, in group 2, calcium phosphate granules were used and in group 3, a mixture of calcium phosphate granules and bone matrix gelatin were used to fill the bone defect. Rabbits of each group were euthanized at 45 days intervals for evaluation of histopathological and biomechanical changes. Histopathology finding in control group, defect seemed to be filled with connective tissue and bone marrow spaces and in spite of a poor osteogenic activity. In group 2, defect has been filled by newly formed bone. Active osteogenesis seemed. In group 3, young bone trabeculas increased in number and bone trabeculas more organized. Biomechanical results show that the mean load for fracturing in group 3 was significantly higher than group 1 and group 2 (p=0/000). Results was showed significant changes between the group 2 and control group (p=0/000). In this study calcium phosphate bone granules and bone matrix gelatin mixture is intended to be suitable for defects of any shape; this mixture is the osteoinductive property which provides better to the healing site.
Authors and Affiliations
Ghafour Mousavi *| Department of Clinical Science, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran, email: gh_mousavi@iaut.ac.ir, Daryoush Mohajeri| Department of Pathobiology, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran, Mostafa Rezaei| Department of Polymer Engineering, Institute of Polymeric Materials, Sahand University of Technology, Tabriz, Iran, Masoud Aghapour| Graduate of Veterinary Medicine, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran, Siavash Maghsoudi| Graduate of Veterinary Medicine, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Keywords
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