Restorative effect of Eclipta alba in CCl4 induced hepatotoxicity in male albino rats
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2011, Vol 1, Issue 4
Abstract
Objective: To elucidate the restorative effect of the aqueous leaf extract (85%) of the traditional medicinal plant Eclipta alba (E. alba) against CCl4 induced hepatotoxicity in male albino rats. Methods: Restorative activity was assessed using CCl4-induced hepatic injury in rats by monitoring biochemical parameters. Biochemical markers of hepatic damage such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were assessed in serum. The oxidative stress was evaluated by measuring the levels of thiobarbutric acid reactive substance (TBARS), hydroperoxides, activity levels of enzymes viz. superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione-s-transferase (GST) in hepatic tissue. Results: CCl 4 and olive oil mixture (1:1 dosage of 1 mL/kg b.w.) induced oxidative stress was indicated by elevated levels of TBARS and hydroperoxides, and augmented levels of serum AST, ALT and ALP. The depleted activity levels of antioxidant enzymes such as SOD, CAT, GPX and GST were found in CCl 4 induced animals. The aqueous leaf extract of E. alba (250 mg/kg b.w.) ameliorated the effects of CCl 4 and returned the alter levels of the biochemical markers near to the normal levels. Conclusions: The study indicates that aqueous leaf extract of E. alba has potential restorative effect on CCl4 induced hepatotoxicity in male albino rats.
Correlation of serum paraoxonase activities in known cases of 130 elderly hypertensive South Asian aged 56-64 years - a hospital based study
Objective: To evaluate paraoxonase activity, antioxidant status and lipid peroxidation in hypertensive participants and to address the hypothesis that oxidative modifications of lipids due to hypertension can cause chang...
Evaluation of phytochemical constituents by GC-MS and antidepressant activity of Peganum harmala L. seeds extract
Objective: To identify the phytochemical constituents of Peganum harmala L. (P. harmala) seeds extract by gas chromatography-mass spectrometer (GC-MS) and evaluate their antidepressant activity. Methods: The seeds extrac...
Effective herbs on the wound and skin disorders: a ethnobotanical study in Lorestan province, west of Iran
Objective: To identify medicinal plants in Lorestan Province (west of Iran) in treatment of wound healing and skin lesions. Methods: Questionnaire were made by health volunteers who were trained. The questionnaire about...
An in vitro antagonistic efficacy validation of Rhizophora mucronata
Objective: To assess the in vitro antimicrobial efficacy of Rhizophora mucronata (R. mucronata) collected from the mangrove wetland of Ayiramthengu (southwest coast of India) against potential human and shrimp pathogens...
Treatment of midesophageal diverticulum by adhesiolysis
Midesophageal diverticulum which has traction in etiology may be asymptomatic or symptomatic. Treatment is changed according to the severity of the symptoms and size of it. Midesophageal diverticula were developed after...