Reverse The Adverse - Reversing Agent (Phentolamine Mesylate) For Local Anaesthesia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Although pain control remains the cornerstone of any oral and dental procedure, prolonged local anesthetic effects may be undesirable in many instances in dental clinical practice. Soft tissue anesthesia can lead to uncontrolled drooling, patient's perceived sense of altered appearance, self inflicted injuries and thermal or chemical burns. Phentolamine mesylate, a nonselective α adrenergic blocking drug is the first therapeutic agent marketed for the reversal of soft tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor. This article reviews the indications, recommended dosage, mechanism of action, pharmacokinetics, clinical studies, complications and adverse effects of phentolamine mesylate for the reversal of soft tissue anesthesia.
Authors and Affiliations
Shijineed . T. K, Kannan Vadakkepurayil, Mereesha . K, Anupam Kumar T. V, Faseela Beegum P. K
Keywords
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