Risk Factor of Multiple Myeloma in Relation to Occupational Exposure to Radiation: A Hospital Based Study at Gauhati Medical College & Hospital, Guwahati, Assam
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Background: The risk factors for multiple myeloma (MM) are not conclusive, because the cause of MM is not clearly known. Researchers believe that MM is most likely the result of many risk factors acting together. Despite recent advances in clarifying the biological mechanisms of MM, there are no established risk factors so far other than factors like male gender, increasing age, African American ethnicity, positive family history of lymphatohematopoietic cancer (LHC) and monoclonal gammopathy of undetermined significance (MGUS). Several studies have shown that during world war people who were exposed to radiation from an atomic bomb blast had a higher risk of developing MM. Other studies also suggests its association with occupational exposure to radiation, but not conclusive. This study aimed to investigate the association between occupational exposure to radiation and development of MM. Methods: This study is based on studies conducted on Risk Factor of Multiple Myeloma with Occupational Exposure to Radiation - A Hospital Based Study at Gauhati Medical College & Hospital, Guwahati, Assam. A total of 100 cases were studied in the Out Patient Department (OPD) of the Clinical Haematology Department, Gauhati Medical College & Hospital, and Guwahati, Assam. Being a descriptive study, the data were procured from the OPD of the same department Results: In the present study 75 (75%) had no history of exposure; 20 (20%), 4 (4%) and 1% patients had history of X-ray, CT scan and professional exposure of radiation. there exists a significant difference (p<0.0001) in the number of patients belonging to the two groups, exposure to radiation and non-exposure. Also there exists a significant difference (p<0.0001) in the number of patients with reference to exposure to different types of radiation. Conclusions: Factors with significant risk for development of multiple myeloma are – X-ray exposure for more than four years.
Authors and Affiliations
Lohit Kumar Kalita, Mansi Mondol, Pabitra Kamar Gogoi, Umesh Ch. Sarma
Keywords
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- EP ID EP543981
- DOI 10.21276/ijmrp.2017.3.2.035
- Views 68
- Downloads 0
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