Risk of hypertension in subclinical hypothyroidism
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Background and Objectives: Hypothyroidism is associated with increased risk for cardiovascular disease by increasing the risk for hypertension, hypercholesterolemia, and increased low-density lipoprotein cholesterol levels. Thyroid hormones play an important role in regulating lipid metabolism and maintaining the blood pressure. Subclinical hypothyroidism is found to progress to overt hypothyroidism. But whether subclinical hypothyroidism (SCH) is associated with increased blood pressure and dyslipidemia is controversial aspect. Studies revealing risk of hypertension leading to cardiovascular disease in subclinical hypothyroidism are conflicting. This study was done to evaluvate the risk of hypertension in subclinical hypothyroidism. Materials and Methods: 30 SCH cases were compared with 30 euthyroid controls. Serums T3, T4, TSH were estimated by ELISA method, Serum Total-Cholesterol, HDL-Cholesterol by enzymatic CHOD-PAP method, Triglycerides by GPO-POD method and LDL-Cholesterol using Friedewald formula, and blood pressure was measured by using mercury sphygmomanometer. Results: Significant increase was found in the mean serum levels of TSH (P<0.001), Total cholesterol (p<0.001), Triglycerides (P<0.001), LDL Cholesterol (P<0.001), HDL-Cholesterol (P<0.001), systolic blood pressure (p<0.001) and diastolic blood pressure (P<0.001). No significant change was observed in levels of serum T4. Percentage of subjects with increased Total Cholesterol, Triglycerides, LDL-C, systolic blood pressure and diastolic blood pressure and decreased HDL-C were more in subclinical hypothyroidism as compared to euthyroid controls indicating the hypertensive changes in subclinical hypothyroidism. Conclusion: The Study revealed that hypertension is seen in subjects with subclinical hypothyroidism. This points to the importance of screening the patients for subclinical hypothyroidism and prevent them from progressing to overt hypothyroidism, hypertension and cardiovascular diseases.
Authors and Affiliations
Smita Kottagi, Triveni Jambale, Srinivas Deshpande, Amareshwar Malagi
Keywords
Related Articles
- EP ID EP258980
- DOI -
- Views 174
- Downloads 0
Serum Ceruloplasmin/Albumin ratio in HIV patients with anti retroviral therapy
Background: HIV is a life long illness and requires regular monitoring and treatment as per the clinical, immunological and viral status of HIV patients. The various simple cost effective prognostic markers need to be ex...
Enzymatic and non-enzymatic antioxidants changes in precancerous and cancerous lesions of oral cavity
Background: Involvement of ROS in the development of tobacco related oral carcinogens is speculated. Little is known about the status of ROS scavengers or antioxidant enzymes in association with precancerous and cancerou...
Utility of serum HE4 level to diagnose epithelial ovarian cancer - A cross sectional study
Background: Epithelial Ovarian cancer is most common and lethal gynecological malignancy. Diagnosis of ovarian cancer at early stage remains in challenge because of unavailability of accurate tumor marker that detects ca...
A study of serum HDL with respect to exercise and vitamin B3 supplementation at tertiary health care centre
Background: Despite numerous therapeutic advances, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in world wide. Although statins reduce coronary artery disease by approximately 30% Aim...
Is saliva, a possible alternative to correlate serum lipids? - An exploratory study
Background and Objective: Serum lipid panel screening has become a routine check up to rule out cardiovascular risks in many clinical conditions & it mainly serves as diagnostic, prognostic & monitoring purposes. But the...