Risk of hypertension in subclinical hypothyroidism
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Background and Objectives: Hypothyroidism is associated with increased risk for cardiovascular disease by increasing the risk for hypertension, hypercholesterolemia, and increased low-density lipoprotein cholesterol levels. Thyroid hormones play an important role in regulating lipid metabolism and maintaining the blood pressure. Subclinical hypothyroidism is found to progress to overt hypothyroidism. But whether subclinical hypothyroidism (SCH) is associated with increased blood pressure and dyslipidemia is controversial aspect. Studies revealing risk of hypertension leading to cardiovascular disease in subclinical hypothyroidism are conflicting. This study was done to evaluvate the risk of hypertension in subclinical hypothyroidism. Materials and Methods: 30 SCH cases were compared with 30 euthyroid controls. Serums T3, T4, TSH were estimated by ELISA method, Serum Total-Cholesterol, HDL-Cholesterol by enzymatic CHOD-PAP method, Triglycerides by GPO-POD method and LDL-Cholesterol using Friedewald formula, and blood pressure was measured by using mercury sphygmomanometer. Results: Significant increase was found in the mean serum levels of TSH (P<0.001), Total cholesterol (p<0.001), Triglycerides (P<0.001), LDL Cholesterol (P<0.001), HDL-Cholesterol (P<0.001), systolic blood pressure (p<0.001) and diastolic blood pressure (P<0.001). No significant change was observed in levels of serum T4. Percentage of subjects with increased Total Cholesterol, Triglycerides, LDL-C, systolic blood pressure and diastolic blood pressure and decreased HDL-C were more in subclinical hypothyroidism as compared to euthyroid controls indicating the hypertensive changes in subclinical hypothyroidism. Conclusion: The Study revealed that hypertension is seen in subjects with subclinical hypothyroidism. This points to the importance of screening the patients for subclinical hypothyroidism and prevent them from progressing to overt hypothyroidism, hypertension and cardiovascular diseases.
Authors and Affiliations
Smita Kottagi, Triveni Jambale, Srinivas Deshpande, Amareshwar Malagi
Keywords
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