Serum Ceruloplasmin/Albumin ratio in HIV patients with anti retroviral therapy
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 1
Abstract
Background: HIV is a life long illness and requires regular monitoring and treatment as per the clinical, immunological and viral status of HIV patients. The various simple cost effective prognostic markers need to be examined as substitute to CD4 and viral load. Serum Ceruloplasmin/Albumin ratio has already proved its significance in monitoring of progression and treatment in various inflammatory diseases like tuberculosis. Objective: To estimate serum Ceruloplasmin /Albumin ratio in HIV patients with antiretroviral therapy. Material and Methods: It is a case control study. The study was conducted on 50 clinically diagnosed patients of HIV attending Centre of Excellence of HIV AIDS Sir JJ Group of Hospitals Mumbai. Fifty HIV seronegative age and sex matched subjects were taken as controls. Venous blood about 5 ml was collected and serum ceruloplasmin and serum albumin were measured on autoanalyser. Results: A statistically significant increased value of Ceruloplasmin /Albumin ratio was noted in HIV patients as compared to control (p<0.001). Conclusion: Our study may be evident of Ceruloplasmin/ Albumin ratio increase in HIV patients on ART. Further study of this ratio with different stages of HIV may assist in monitoring prognosis and treatment of HIV patients on antiretroviral therapy.
Authors and Affiliations
H M Deshmukh, R V Bhivapure, V W Patil, V S Nagar
Keywords
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- EP ID EP442130
- DOI 10.26611/1002813
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