Role of Adjuvant Therapy in Osteoradionecrosis (Orn) and Bisphosphonate Induced Osteonecrosis of Jaw (Bronj)
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 5
Abstract
Aim; A treatment procol with pentoxifylline(PT) and A- tocoferol combination therapy to assess the utility along with standard antimicrobial therapy in a series of cases of ORN (osteoradionecrosis) of jaw and BRONJ. Material & Method: A total of 13 cases of ORN and BRONJ associated with pathological fracture of jaw and wound dehiscence of more than 03 cm was considered in this prospective study. A combination therapy of pentoxifylline (PT) and A- tocoferol was prescribed with standard antimicrobial therapy. PT was prescribed at 400 mg twice daily and A- tocoferol was prescribed at 1000 IU once daily. Chlorhexidine (0.12%), 10-15 ml rinsed more than 30 seconds twice daily. The entire protocol was for two months pre and postoperatively. A treatment response rating scale was defined for categories of excellent, good, fair, and poor. Results: A decrease in overall occurrence of symptoms, and signs was achieved in all the cases. Changes were evident even before surgical intervention. All patients were without pain, erythema, or purulence following initiation of treatment with PT and A tocoferol, in post-operative period. The therapy was beneficial in cases of ORN and BRONJ. Conclusion: this treatment protocol with PT and A-tocoferol therapy is highly beneficial in cases of ORN and BRONJ without any adverse effects.
Authors and Affiliations
Maj A Navin Kumar, Brig I D Roy, Maj Gaurav Dua, Maj Sandeep Mehta
Keywords
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