Role of Antral Follicle Count as a Marker of Ovarian Reserve and Its Correlation with Antimullerian Hormone and Follicle Stimulating Hormone
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Introduction: In recent time there has been a significant increase in subfertile couples in India. Few studies labeled Antral Follicle Count (AFC) as more accurate biomarker in comparison to Anti-Mullerian Hormone (AMH) for assessing female subfertility. However limited Indian data is available and we continue to follow western literature irrespective of difference in genetic make-up and different socio-economic status. Aims: To study age related trends in markers of ovarian reserve and their correlation with each other. Material and Methods: This was a prospective study where 50 patients with complaints of infertility were included. Subjects underwent transvaginal sonography on day 3 of menstrual cycle for estimation of AFC and Total ovarian volume (TOV). Blood sample was taken on the same day to measure hormonal profile related to infertility work-up. The data was subjected to statistical analysis and correlation coefficients were determined. p-value <0.05 was considered statistically significant for all analysis. Results: There was statistically significant negative correlation between age as compared to mean AFC (p < .05) and mean AMH (p <.05). However, Follicle stimulating hormone (FSH) showed positive correlation with age. AFC was found to be more statistically sensitive marker as compared to AMH and FSH. Conclusion: AFC is a reliable marker of ovarian reserve assessment and more sensitive to age related decline in ovarian reserve.
Authors and Affiliations
Shourya Sharma, Arvind Shukla, Arjit Agarwal, Rehana Nazam, Yuktika Gupta
Keywords
Related Articles
- EP ID EP538902
- DOI 10.21276/ijmrp.2018.4.2.028
- Views 76
- Downloads 0
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