Role of Glutamine Supplemented Total Parenteral Nutrition (Tpn) in Severe Acute Pancreatitis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Aims and objectives: We conducted this study to evaluate the role of glutamine supplemented total parenteral nutrition (TPN) in severe acute pancreatitis. Methods: Forty patients with severe acute pancreatitis admitted at Rajendra institute of medical Sciences ,Ranchi, over a period of one year( July 2012 to June 2013) were randomly divided into two therapeutic groups. Patients in group 1( 19 in no) and group 2 (21 in no.) were treated with standard TPN and glutamine supplemented TPN respectively. Patients were assessed for nutritional parameters, the incidence of complications, mortality, length of hospital stay(LOS) and length of TPN. Results: Majority of patients were male in both groups(60 % in group 1 vs. 62% in group 2) and the average age of presentation was also same(41.13+ 4.46 years in group 1 vs.39+3.96 years in group 2). Gall stone was the most common etiological factor followed by alcohol. The incidence of complications in group 1 was much higher(40.25%) than those in group 2 (30%). Mortalities for group 1 and 2 were 15.78 %(3/19) and 9.52%(2/21) respectively. The length of hospital stay in group 1(21.08+2.80days) was longer than those of group 2 (19.33+2.62 days). The length of TPN was alsolonger in group 1 (14.47+2.72 days) than those of group 2 (10.56+2.21 days). Conclusion: Glutamine supplemented TPN did not significantly decrease the mortality or rate of complications but it reduced the number of hospital days admission and duration of TPN. Further studies with large number of patients is needed in Indian setting.
Authors and Affiliations
Gautam Chandra, Mananjay Prasad, Ranveer Singh Rana, Rajeev Ranjan Kumar, Abhinav Shekhar, Sharwan Kumar
Recent Approaches in Biomimetic Dentistry: A Review
Biomimetics is the study of the formation, structure, or function of biologically produced substances and materials and biological mechanisms and processes especially for the purpose of synthesizing similar products by a...
Evaluation of Different Finishing/Polishing Systems of a NanoHybrid Resin Based Composite Restorations
Objectives: This study was conducted to evaluate quantitavely and qualitatively the effect of different Finishing/Polishing systems of a nano-hybrid resin-based composite. Materials and Methods: Forty cylindrical split m...
A Hospital-Based Clinical Study of Herpes Zoster- A report of 113 cases
Herpes zoster is caused by “varicella zoster virus”- a neurodermotropic virus which is distributed worldwide. It is characterized by unilateral radicular pain and grouped vesicular eruption that is generally limited to t...
A Study on Association of Serum Levels of Lipoprotein(A) And Stroke Severity
Introduction: Stroke or cerebrovascular accident is a major public health problem in India .stroke presents as an emergency clinical situation. The risk factors of stroke are hypertension, diabetes mellitus, dyslipidemia...
Ossification of Ligamentum Flavum: A Morphological Study In Dried Vertebrae
AIM: To find out the prevalence, segmental distribution and morphological characteristics of ossification of ligamentum flavum in thoracic spine. MATERIALS AND METHOD: We examined 1786 numbers of dried thoracic vertebrae...