Role of Iron Metabolic Indices in Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Introduction:Type 2 Diabetes Mellitus is a major growing health issue worldwide. Role of micro nutrients is not well established. Serum Ferritin, an acute phase reactant is a marker of iron stores in the body. Iron overload is increasingly being connected to insulin resistance in type 2 Diabetes Mellitus Patients. Aims & Objectives:1)Study of levels of Serum Iron, Total Iron Binding Capacity (TIBC), Ferritin in Type 2 Diabetes Patients to find any statistically significant relationship between Iron status and Diabetes mellitus.2)To find association of elevated Serum Ferritin level with Diabetes mellitus & its Correlation with Glycated Hemoglobin (HbA1C). Materials & Methods: The Study Population consist of 120 individuals. Out of them 60 were type 2 Diabetes Patients(Cases) and 60 were normal healthy individuals (Controls). Comparison of Serum Iron, TIBC, Ferritin, FBS, PPBS and HbA1C was done between cases & Controls. Correlation of Serum Ferritin with HbA1C in test group was seen. Results:We found that FBS(P<0.05), PPBS(P<0.05), HbA1C(P<0.05) and Serum Ferritin (P<0.05) of case group were significantly higher than that of Control group. Stastistically highly significant Positive Correlation is observed between Ferritin & HbA1C levels in Type 2 Diabetes with (r =0.6083) and (P=0.001).We also observed that there was no increase in serum Iron among those with DM. Conclusion: We can Conclude that Serum Ferritin can be considered as sensitive marker of Iron status in Diabetic group. Excess tissue Iron will increase the production of free radicals which in turn amplifies the steps involved in inflammatory lesion. Serum Iron, TIBC & Ferritin may be monitored at regular intervals in those with Diabetes mellitus so that appropriate measures can be taken.
Authors and Affiliations
Dr. Sowjanya Y, Dr. V. Siva Prabodh, Dr. Desai Vidya Sripad
Keywords
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- EP ID EP250751
- DOI 10.9790/0853-1612050105
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