Role of microalbuminuria and hs-CRP in Helicobacter pylori infected type 2 diabetes mellitus in Eastern India

Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8

Abstract

Background: Helicobacter pylori (HP) infections are one of the few commonest worldwide which affects approximately 50% of the overall population. It is reported that high serum levels of C-reactive protein (CRP) is a novel cardiovascular risk factor that impairs endothelial function. H. Pylori infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Thus our study attempts to find the levels of microalbuminuria between H. pylori infected patients and non-infected patients in diabetes mellitus and establish its association with blood glucose levels. Materials and Methods: The case control study consists of 98 diabetic patients where 52 were clinically suspected case of H. Pylori infection and 46 without H. Pylori infection in medicine department. Serum hs CRP levels were determined with a high-sensitivity nephelometric method. Urinary albumin excretion was measured by nephelometric test for the measurement of microalbumin in urine. Three endoscopic biopsy samples were obtained from the antral mucosa of each patient. The first two biopsy samples were placed into 10% formol solution and dyed by Giemsa and hematoxylin-eosin while the third sample was given for rapid urease test and investigated for H. pylori. Results: The presence of H. pylori infection was detected in 52 of 98 diabetic patients (53.06%). The ESR and hs-CRP levels were elevated in H. Pylori infected diabetes cases as compared to non-infected diabetics www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i8.61 Syamal Modi et al JMSCR Volume 05 Issue 08 August 2017 Page 26351 JMSCR Vol||05||Issue||08||Page 26350-26356||August 2017 which were found statistically significant. The Microalbumin levels were higher in diabetic patients infected by H. pylori compared to non-infected patients (185.3 ± 90.5 vs 128.1 ± 42.6; p <0.001). However, a high positive correlation was observed between ESR with hs-CRP level (r = 0.825; P = <0.001) among H. Pylori infected diabetes subjects while no correlation was seen in non-infected diabetics (r = 0.279; P = 0.098). Conclusions: We have also observed an increase in hs-CRP and ESR levels in H.pylori infected diabetics which are also in confirmation with other fewer studies. Moreover, an association is observed between ESR and Hs-CRP in H. Pylori infected diabetics which suggest a plausible role in the pathogenesis and could be used as screening markers of the disease. hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.

Authors and Affiliations

Mr Krishanu Pal

Keywords

Related Articles

PET scan Misleads to Diagnosis but Leads to Correct Operative Approach

A 67 year old female presented with high grade fever and abdominal pain since one week. Pain in abdomen was predominantly in the left lumbar region. She also had anorexia and weight loss. Patient had diabetes mellitus si...

Omental Infarction: A Broad View

Omental infarction is one of the rare causes of acute abdomen which is often mistaken for acute appendicitis. Though there is no evidence of exact etiology, many of the predisposing factors have been attributed especiall...

The Experience of Household Food Insecurity among Elderly

Background: Food insecurity has been associated with a wide array of negative health outcomes both among the young and old. Objective: to compare food insecurity status as measured by the Household Food Insecurity Access...

Case Report - Unusual Case of AV Malformation Presenting as Saphena Varixin a 3-Year-Old Child

Saphena varix may be defined as an abnormal dilatation of the distal part of the Great Saphenous Vein (GSV) near its junction with femoral vein.1 Saphena Varix is a venous anomaly affecting the upper part of great saphen...

Efficiency of Single Dose Antibiotic Prophylaxis in Inguinal Hernioplasty

Introduction and objectives: Surgical site infection (SSI) is the most frequent complication in inguinal hernioplasty.SSI is related with an increase in length of stay and costs and a decrease in quality of life. Use of...

Download PDF file
  • EP ID EP527175
  • DOI -
  • Views 68
  • Downloads 0

How To Cite

Mr Krishanu Pal (2017). Role of microalbuminuria and hs-CRP in Helicobacter pylori infected type 2 diabetes mellitus in Eastern India. Journal of Medical Science And clinical Research, 5(8), 26350-26356. https://europub.co.uk/articles/-A-527175