ROLE OF MRI T2* IMAGING IN EVALUATION OF LIVER AND CARDIAC IRON OVERLOAD, ITS CORRELATION WITH SERUM FERRITIN AND CARDIAC 2D ECHO CORRELATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 4
Abstract
BACKGROUND Patients with chronic haemolytic anaemia like thalassemia and sickle cell anaemia need repeated blood transfusions, which lead to iron overload and cellular damage, especially in the heart and liver. Classically, serum ferritin and liver biopsy have been used to monitor patient’s response to chelation therapy. Magnetic resonance imaging (MRI) has been proved effective in detecting and quantifying iron in the heart and liver. The aim of this study is to find out the correlation between the quantification of cardiac and liver iron overload in repeatedly transfused patients using MRI T2* imaging with serum ferritin and cardiac output using 2D echocardiography respectively. MATERIALS AND METHODS In 400 cases of repeatedly transfused patients, hepatic and myocardial iron overload was measured by multi-breath holds MRI T2* and compared to serum ferritin (a traditional marker of iron overload). RESULTS 1. Moderate positive correlation was observed between Cardiac T2* measurements and 2D echo (ejection fraction) (P < 0.0001, r= 0.39). 2. Moderate positive correlation was observed between serum ferritin and liver T2* MRI (P < 0.0001, r= 0.41). CONCLUSION Routine evaluation of liver and heart iron content using MRI T2* is suggested to better evaluate the haemosiderosis status in patients with chronic haemolytic anaemia. Also, regular follow-up studies can alleviate the need for repeated liver biopsy and detect cardiac iron overload before starting of cardiac dysfunction.
Authors and Affiliations
Sanjiv Patel, Sapna Patel, Hardik Jadav, Kushal Makwana
Keywords
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- EP ID EP285879
- DOI 10.14260/jemds/2018/103
- Views 69
- Downloads 0
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