Role of Ormeloxifene in Treatment of Abnormal Uterine Bleeding (AUB) In Comparison with Other Hormanal Treatment Modalities
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Introduction: Abnormal uterine bleeding (AUB) is state of abnormal bleeding from uterus without any clinically detectable organic, systemic and iatrogenic causes. AUB is major and one of the most distressing gynaecological problems for both patient and clinician. Aims and objective- To compare the effect of ormeloxifene for treatment of AUB and its comparison with Norethisterone and oral contraceptives in different age groups in view of efficacy, compliance, complication and follow-up in terms of avoiding hysterectomies. Material and Methods: 300 cases of AUB were divided into three groups during study period September 2016 to September 2017. Group A (n=100) were given ormeloxifene to received 60 mg twice weekly for 12 week followed by once weekly for 3 months. Group B (n=100) were given Norethisterone 10 mg bd in every cycle from day 5 to day 25 for 6 month and Group C were given oral contraceptive pills (OCP) from day 1 to day 21 of menstrual cycle for six cycle. Results: There is significant reduction of PBAC score from 127 to 36 after six month of treatment in group A, 127 to 77 in group B whereas 128 to 96 in group C. Mean pre-treatment endometrial thickness decreased markedly in ormeloxifene group from 9.8 mm to 5.8 mm as compared to norethisterone (9.7-6.4mm) and OCP group (9.7-7.7mm).Complications such as hypo amenorrhea 73% patient and about 15% develop amenorrhea. Conclusion: Ormeloxifene has better compliance and acceptability with marked relief of symptoms. Women who underwent hysterectomy after treatment were also significantly less in ormeloxifene group. Hence, ormeloxifene should be considered the first choice in management of AUB especially in perimenopausal age group where amenorrhea is acceptable.
Authors and Affiliations
Dr. Himanshi Gupta
Keywords
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