Role of Ormeloxifene in Treatment of Abnormal Uterine Bleeding (AUB) In Comparison with Other Hormanal Treatment Modalities
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Introduction: Abnormal uterine bleeding (AUB) is state of abnormal bleeding from uterus without any clinically detectable organic, systemic and iatrogenic causes. AUB is major and one of the most distressing gynaecological problems for both patient and clinician. Aims and objective- To compare the effect of ormeloxifene for treatment of AUB and its comparison with Norethisterone and oral contraceptives in different age groups in view of efficacy, compliance, complication and follow-up in terms of avoiding hysterectomies. Material and Methods: 300 cases of AUB were divided into three groups during study period September 2016 to September 2017. Group A (n=100) were given ormeloxifene to received 60 mg twice weekly for 12 week followed by once weekly for 3 months. Group B (n=100) were given Norethisterone 10 mg bd in every cycle from day 5 to day 25 for 6 month and Group C were given oral contraceptive pills (OCP) from day 1 to day 21 of menstrual cycle for six cycle. Results: There is significant reduction of PBAC score from 127 to 36 after six month of treatment in group A, 127 to 77 in group B whereas 128 to 96 in group C. Mean pre-treatment endometrial thickness decreased markedly in ormeloxifene group from 9.8 mm to 5.8 mm as compared to norethisterone (9.7-6.4mm) and OCP group (9.7-7.7mm).Complications such as hypo amenorrhea 73% patient and about 15% develop amenorrhea. Conclusion: Ormeloxifene has better compliance and acceptability with marked relief of symptoms. Women who underwent hysterectomy after treatment were also significantly less in ormeloxifene group. Hence, ormeloxifene should be considered the first choice in management of AUB especially in perimenopausal age group where amenorrhea is acceptable.
Authors and Affiliations
Dr. Himanshi Gupta
Keywords
Related Articles
- EP ID EP495693
- DOI -
- Views 130
- Downloads 0
To study the cutaneous manifestations in patients with CKD in Hadoti Region of Rajasthan.
Background- The chronic kidney disease (CKD) is defined as the presence of kidney damage or decreased level of kidney function for three months or more, irrespective of etiology. Methods- This study was undertaken to stu...
Primary Osteosarcoma of the Breast: A Rare Case Report and Review of Literature
Unlike skeletal osteosarcoma, primary osteosarcoma of the breast is extremely rare tumor. We report very rare case of primary osteosarcoma of the breast in a 50-year old female. Core needle biopsy of the breast lump was...
Antibiotic Prescriptions Pattern in Paediatric In-Patient Department with Lower Respiratory Tract Infection at a Tertiary Care Hospital, Davangere.
The Objective of the study was carried out with the aim to assess the prescribing pattern of antibiotic drugs with Lower Respiratory Tract Infection (LRTI) at a tertiary care teaching Hospital, Davangere using WHO core d...
A Comparative Histopathological Study of Lesions of Nasal Cavity, Nasopharynx And Paranasal Sinuses At Tertiary Care Hospital of Western Rajasthan
Background- A variety of non-neoplastic and neoplastic conditions involve the nasal cavity (NC), paranasal sinuses (PNS) and these are very common lesions encountered in clinical practice. A large number of diseases affe...
To evaluate the role of nasogastric tube as a guide to facilitate nasotracheal intubation.
Nasotracheal intubation is an established airway management technique in various intra-oral and oropharyngeal surgical procedures. Nasal trauma is chief complication associated with it. In order to overcome nasal trauma...