Role of oxidative stress in thyrotoxicosis
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 25, Issue 1
Abstract
Thyrotoxicosis is a clinical syndrome that results when excessive levels of active thyroid hormones T3 and T4 are secreted into the circulation. In thyrotoxicosis oxidative stress is implicated in the causation of clinical features like myopathy, myocardial insufficiency and ophthalmopathy. Oxidative change in thyrotoxicosis was assessed by measuring level of lipid peroxidation product malondialdehyde (MDA) and activity of antioxidant enzyme superoxide dismutase (SOD) in the blood of 18 thyrotoxic patients and 22 healthy euthyroid controls. Serum MDA level was significantly increased and serum SOD activity was ver The present study confirms the presence of oxidative stress in thyrotoxicosis. This warrants nutritional support with antioxidant agents in thyrotoxicosis.
Authors and Affiliations
Geetha P A, Ajaykumar B, Parvathi K, Sreejayan M P
Keywords
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