Role of Polysaccharides isolated from Nepeata septemcrenata in diabetic albino rats
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 4
Abstract
The present study was designed to investigate the antidiabetic activity of polysaccharide extracted from Nepeta septemcrenata (N. septemcrenata). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (30 mg/kg b.w.). Twenty four adult male albino rats were divided into control group, diabetic group, diabetic group treated with gliclazide as a reference drug (10mg/kgb.w.) and diabetic group treated with polysaccharide extracted from N. septemcernata (50mg/kg b.w). The experiment was lasted for 21 days. STZ was significantly increased blood glucose, Alanin aminotransferase (ALT), Asparate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol, triglyceride and amylase associated with significantly decrease of total protein and albumin levels. Administration of polysaccharide extracted from N. septemcrenata significantly attenuated glucose, α-amylase, ALT, AST, ALP, total protein, albumin, total cholesterol and triglyceride. In Conclusion: The polysaccharide extracted from N. septemcrenata display a significant antidiabetic properties in comparison with gliclazide.
Authors and Affiliations
Sawsan Ahmed Nasr| Physiology Department,National Organization for Drug Control and Research (NODCAR), Amel Abd El-Moneim Saad| Biochemistry Department,National Organization for Drug Control and Research (NODCAR), Mai Selmy khader| Botany DepartmentØNational Organization for Drug Control and Research (NODCAR)
Keywords
Related Articles
- EP ID EP3602
- DOI -
- Views 335
- Downloads 21
A STRATEGY TO INTEGRATE CLINICALPHARMACOLOGY TEACHING AMONG MEDICAL UNDERGRADUATES IN TERTIARY CARE CENTRE OF UTTARAKHAND.
To impart concept of clinical pharmacology knowledge to the undergraduate MBBS second professional students.A total of 705 cases were followed up by the undergraduate students during second professional MBBS at Governmen...
Characteristics of liposome used for drug delivery system
Liposome as a drug delivery system is emerges as a one of the potential in pharmaceutical industries. The properties of nano-medicines such as release from dosage forms at specific sites as well as drug circulation and a...
INSOMNIA WITH HOMOEOPATHY
Most people encounter sleep difficulties from time to time, often related to stress or pain. Many of these bouts get better without treatment. Unfortunately, in a significant proportion of the population, sleep problems...
DETECTION OF EPSTEIN - BARR VIRUS IN LYMPHOMA LESIONS AMONG SUDANESE PATIENTS USING LMP-1 MONOCLONAL ANTIBODY
OBJECTIVE: this was a retrospective descriptive study aimed to investigate the association of EBV with different types of lymphoma in Sudanese patients. METHODS: Fifty paraffin-embedded formalin-fixed tissue sections of...
EVALUATION OF PLATELET COUNT AND PLATELET INDICES IN PATIENTS WITH ACUTE MALARIA IN SHENDI LOCALITY
Background: Malaria is the commonest cause of morbidity in Africa. This study describes altered platelet count and platelet indices in patients with acute malaria caused by Plasmodium falciparum, Plasmodium vivax and pla...