Role of Polysaccharides isolated from Nepeata septemcrenata in diabetic albino rats
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 4
Abstract
The present study was designed to investigate the antidiabetic activity of polysaccharide extracted from Nepeta septemcrenata (N. septemcrenata). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (30 mg/kg b.w.). Twenty four adult male albino rats were divided into control group, diabetic group, diabetic group treated with gliclazide as a reference drug (10mg/kgb.w.) and diabetic group treated with polysaccharide extracted from N. septemcernata (50mg/kg b.w). The experiment was lasted for 21 days. STZ was significantly increased blood glucose, Alanin aminotransferase (ALT), Asparate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol, triglyceride and amylase associated with significantly decrease of total protein and albumin levels. Administration of polysaccharide extracted from N. septemcrenata significantly attenuated glucose, α-amylase, ALT, AST, ALP, total protein, albumin, total cholesterol and triglyceride. In Conclusion: The polysaccharide extracted from N. septemcrenata display a significant antidiabetic properties in comparison with gliclazide.
Authors and Affiliations
Sawsan Ahmed Nasr| Physiology Department,National Organization for Drug Control and Research (NODCAR), Amel Abd El-Moneim Saad| Biochemistry Department,National Organization for Drug Control and Research (NODCAR), Mai Selmy khader| Botany Department،National Organization for Drug Control and Research (NODCAR)
Keywords
Related Articles
- EP ID EP3602
- DOI -
- Views 367
- Downloads 21
IDENTIFICATION OF CLINICALLY RELEVANT MYCOBACTERIUM OTHER THAN TUBERCULOSIS (MOTT) SPECIES BY REAL-TIME PCR COUPLED WITH A HIGH-RESOLUTION MELTING SYSTEM
A real-time PCR coupled with a high-resolution melting curve assay for identifying clinically relevant MOTT species was developed and evaluated using 6 reference strains and 186 Culture isolates. Concordant results were...
COMPARISON BETWEEN COBAS E411 AND ICT IN DIAGNOSIS OF HEPATITIS B VIRUS
Background: Hepatitis B is one of the world’s most common and serious infectious diseases. It is estimated that more than one third of the world’s population has been infected with hepatitis B virus Differentiation betwe...
A Novel Gradient RP-HPLC Method Development for Bortezomib in Parenteral Dosage Form
The objective of present study was the development of gradient RP-HPLC method for the estimation of bortezomib in parenteral dosage form. The analysis was performed on Hypersil C18 column (250 x 4.6mm) with mobile phase...
EMULGEL: A NOVEL APPROACH TO TOPICAL DRUG DELIVERY
Emulgel is an emerging topical drug delivery system to which if more effort is done towards its preparations with more number of topically effective drugs it will prove a boon for derma care products and cosmetic produc...
ISOLATION OF FOUR FUROQUINOLINE ALKALOIDS FROM TECLEA NOBILIS AND THEIR ACTIVITY AGAINST SCHISTOSOMA MANSONI MIRACIDIA
Schistosomiasis is one of the neglected diseases affecting approximately 200 million people worldwide. In this research, we isolated and evaluated the antimiracidial activity of secondary metabolites from Teclea nobilis...