Role of Polysaccharides isolated from Nepeata septemcrenata in diabetic albino rats
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 4
Abstract
The present study was designed to investigate the antidiabetic activity of polysaccharide extracted from Nepeta septemcrenata (N. septemcrenata). Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (30 mg/kg b.w.). Twenty four adult male albino rats were divided into control group, diabetic group, diabetic group treated with gliclazide as a reference drug (10mg/kgb.w.) and diabetic group treated with polysaccharide extracted from N. septemcernata (50mg/kg b.w). The experiment was lasted for 21 days. STZ was significantly increased blood glucose, Alanin aminotransferase (ALT), Asparate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol, triglyceride and amylase associated with significantly decrease of total protein and albumin levels. Administration of polysaccharide extracted from N. septemcrenata significantly attenuated glucose, α-amylase, ALT, AST, ALP, total protein, albumin, total cholesterol and triglyceride. In Conclusion: The polysaccharide extracted from N. septemcrenata display a significant antidiabetic properties in comparison with gliclazide.
Authors and Affiliations
Sawsan Ahmed Nasr| Physiology Department,National Organization for Drug Control and Research (NODCAR), Amel Abd El-Moneim Saad| Biochemistry Department,National Organization for Drug Control and Research (NODCAR), Mai Selmy khader| Botany Department،National Organization for Drug Control and Research (NODCAR)
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