The Role of Curcuminoids in Overcome Neurodegenerative Disorders Resulted from Heavy Metal Overload.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 3
Abstract
Iron plays a vital role in brain where it is essential for production of several neurotransmitters, such as serotonin, dopamine, norepinephrine, and γ-aminobutyric acid. But, overload may have neurodegenerative effect due to oxidative metabolism. So, this study aimed mainly to how can overcome neurodegenerative disorders resulted from iron fortified diet using a natural product. We utilized curcumin (25 mg/kg/day) in normal and iron overload experimental rats against control. Iron overload was induced by packed biscuits (50–60 g/day) enriched with ferrous sulphate (0.2%, w/w) daily for 10 weeks. Rats were divided into four groups (n=10), Group I, rats received packed biscuits. Group II, rats received packed biscuits enriched with ferrous sulphate daily for 10 weeks. Group III, rats received curcumin orally. Group IV, rats were given packed biscuits enriched with ferrous sulphate concomitant with curcumin throughout the period of study referred to as treated group. All animals were killed after 10 weeks. The results showed that iron fortified elevated serum iron, ferritin, nitric oxide (NO) and peroxidation value (MDA) but reduced glutathione (GSH) and super oxide dismutase (SOD) were decreased. Also, Monoamine oxidase (MAO) was elevated leading to decrease of serotonin and dopamine. Serotonin, dopamine, GSH and SOD were alleviated significantly by curcumin. Both neuronal NOS (nNOS) expression and inducible NOS (iNOS) expression were elevated in rats fortified with iron overload and were decreased when treated with curcumin but endothelial NOS (eNOS) protein expression was absent in both controls, animals with iron overload. In conclusion, curcumin displayed effective neuroprotective potency. It has MAO inhibitory effects concerned with increasing of some neurotransmitters, such as serotonin, dopamine through iron chelators and antioxidant action.
Authors and Affiliations
Atef E. Abd El-Baky| Biochemistry Department, Faculty of Pharmacy, Minia University, Egypt
Keywords
Related Articles
- EP ID EP1575
- DOI -
- Views 334
- Downloads 23
MICROBIAL SENSITIVITY ASSAY & HPTLC ANALYSIS OF TERMINALIA CATAPPA & ADATHODA VASICA
In the present study anti- bacterial acivity of Terminalia catappa & Adathoda vasica was evaluated to find the zone of inhibition and to set a HPTLC profile of these plant extracts to make out these plants as a source to...
AN EMPIRICAL STUDY ON THE PREVALENCE OF CHILDREN WITH DISABILITY IN MANGALORE
Children with disability are an important social concern in the community. This study aims to report the different types of disability among school going children in Mangalore. Data were collected from the Inclusive Edu...
A REVIEW ON ACNE
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non inflammatory (comedones, op...
Development and Validation of HPLC Method for the Estimation of Anti-HIV Drug Abacavir Sulphate in Bulk and Pharmaceutical Formulations.
Objective: Analytical method development and validation was useful for estimation of drugs in bulk and biological fluids. They help to improve the reliability, consistency and accuracy of analytical data. Present investi...
Transdermal Delivery of Bisoprolol Hemifumarate
The aim of this study was to formulate and evaluate the administration of bisoprolol hemifumarate (BH) using transdermal delivery systems. The following formulae were prepared as a reservoir to be used in batch formula...