Role of selected MGMT polymorphisms in cancer development
Journal Title: Annales Academiae Medicae Silesiensis - Year 2017, Vol 71, Issue
Abstract
Cell DNA is constantly exposed to mutagenic factors. DNA repair mechanisms are very important to provide proper cell functioning and proliferation control. One of the DNA repair mechanisms is based on the O6-methylguanine-DNA methyltransferase enzyme, which provides protection against alkylating agents. Differences in MGMT enzyme activity may be caused by MGMT gene polymorphisms. MGMT polymorphisms may increase cancer risk, e.g. lung cancer or esophageal cancer. In this review we have described the role of some MGMT polymorphisms in cancer development and therapy.
Authors and Affiliations
Paweł Kiczmer, Błażej Szydło, Joanna K. Strzelczyk, Karolina Gołąbek, Zofia Ostrowska
Keywords
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