Role of TGF-β signaling in tumorigenesis
Journal Title: Journal of Medical and Scientific Research - Year 2014, Vol 2, Issue 2
Abstract
Transforming growth factor β (TGF β) is one of the crucial cytokine playing an important role in developmental and pathological conditions. TGF β is primarily Smad mediated signal transducers but it can also cross talk with c-Jun N-terminal kinases (JNK), Mitogen-activated protein kinases (MAP), Phosphoinositide 3 (PI-3) kinase, Akt/protein kinase B signaling pathways to enhance cancer development. During early stages of cancer the TGF β induces a protective cytostatic effect. In advanced stages, TGF β fails to down regulate Myc, a transcription factor which represses expression of p21Cip1 and p15Ink4b involved proliferation and differentiation of normal epithelial cells and thus losses its cytostatic property. TGF β also involves in various metastatic processes including angiogenesis, extracellular modification, epithelial-mesenchymal transition, cell migration, immune suppression. Several preclinical animal model studies have encouraging outcomes, suggesting TGF β as a potential therapeutic target in advanced cancers.
Authors and Affiliations
Venkateshwari A, Vinod C, Pratibha NA, Jyothy A
Keywords
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- EP ID EP608713
- DOI 10.17727/JMSR.2014/2-020
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