Role of Topical Diltiazem and Topical Glyceryl Trinitrate in Chronic Anal Fissure
Journal Title: Isra Medical Journal - Year 2018, Vol 10, Issue 2
Abstract
OBJECTIVE: To compare the role of topical diltiazem and glyceryltrinitrate in terms of healing in chronic anal fissure. STUDY DESIGN: A Randomized Control Trial PLACE AND DURATION: Department of Surgery, Benazir Bhutto Hospital, Rawalpindi from 1st June 2012 to 30th November 2012. METHODOLOGY: All patients with clinical diagnosis of chronic anal fissure were equally divided in two groups. One group received 0.2% glyceryltrinitrate ointment while other received 2% diltiazem paste topically. Both groups were compared in terms of healing and frequency of headache after 6 weeks of treatment. RESULTS: Among total 140 patients, the 85.7% patients had chronic anal fissure posteriorly while rest of patients had it anteriorly. In glyceryltrinitrate group, the healing rate after 6 weeks was 62.9% while in diltiazem group the rate was 78.6% (p value 0.041). The frequencies of headache were 44.3% and 21.4% in glyceryltrinitrate and diltiazem groups respectively (p value 0.004). CONCLUSION: The diltiazem is superior to the glyceryltrinitrate in terms of healing and side effects when used topically for the management of chronic anal fissure. KEYWORDS: Fissure in Ano, Chemical Sphincterotomy, Glyceryltrinitrate Ointment, Diltiazem Paste, Healing, Headache. HOW TO CITE THIS: Altaf B, Shah FH, Akhtar M, Wasim S. Role of Topical Diltiazem and Topical Glyceryl Trinitrate in Chronic Anal Fissure. Isra Med J. 2018; 10(2): 86-90.
Authors and Affiliations
Bilal Altaf
Keywords
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