Role of Total Urinary Hydroxyproline for the Assessment of Fracture Union
Journal Title: Journal of Bone and Joint Diseases - Year 2017, Vol 0, Issue 0
Abstract
Introduction: Predicting the fracture healing outcomes early is one of the most important and fundamental clinical determinations made in Orthopaedics. However, till date there are no methods yet. Materials and methods: In this cohort study, after ethical clearance and informed consent formalities, total 107 patients were analysed. The serial estimation of total urine hydroxyproline was done at different follow-ups and further correlates it with the fracture healing progression measured using RUST score. Results: As per 24th week of radiological follow-up, these patients were divided into two groups: Normal healing (n=91) and Impaired healing (n=16) groups. The total urinary hydroxyproline levels were measured at different follow-ups showed statistically significant difference between normal and impaired healing groups, except at baseline. A statistically significant positive correlation between total urinary hydroxyproline levels with fracture healing progression. Conclusion: The serial monitoring of total urinary hydroxyproline levels can be used as an adjunct to clinical and radiological evidence of fracture healing to predict the outcomes early.
Authors and Affiliations
Sabir Ali, Ajai Singh, Manish Yadav, Abbas Ali Mahdi
Keywords
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