Role of Vesicular Trafficking in Infection and Cancer: A Review
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2016, Vol 2, Issue 1
Abstract
Most of the pathogenic bacteria and viruses are capable of causing variety of infections in the respective hosts. These infectious agents enter and spread inside the host cells via various modes most notable of which is endocytosis machinery. Several pathogenic strains of bacteria like Mycobacterium, Samlonella and viruses like Dengue virus and HIV-1 make use of endocytic trafficking of vesicles to invade the host cells, multiply and exit. Oncogenic mutations accumulate over the time and affect many vesicular trafficking components causing aberrant distribution of cell surface proteins and downstream signalling leading to reckless proliferation of cells. In this paper, we tried to analyse how pathogens exploit vesicular trafficking machinery of cells for their advantage in infection and perturbations in the process leads to neoplasia conditions. Identification of some key proteins participating in the function may lead to development of new anaphylactic or therapeutic interventions.
Authors and Affiliations
Yogesh Kumar Negi, Harsh Kumar
Keywords
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